Primary open angle glaucoma is associated with a specific p53 gene haplotype
Primary open angle glaucoma is associated with a specific p53 gene haplotype
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DOI：
10.1136/jmg.2003.016089
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发表时间：
2004-04-01
影响因子：
4
通讯作者：
Chinnery, PF
中科院分区：
文献类型：
--
作者：
Ressiniotis, T;Griffiths, PG;Chinnery, PF
方法病例和对照确定在获得我们当地研究伦理委员会的批准后，分析了来自英格兰东北部地区的140名POAG患者和73名健康个体的无关白人队列的血液样本，年龄和性别匹配。POAG患者接受Goldmann眼压测量、裂隙灯生物显微镜检查、Humphrey全阈值24：2视野和四镜前房角镜检查。对照组进行相同的检查，省略房角镜检查，用阈上视野代替全阈视野。
METHODS Case and control ascertainment Having obtained approval from our local research ethics committee, blood samples were analysed from an unrelated Caucasian cohort of 140 POAG patients and 73 healthy individuals, matched for age and gender, from the north east area of England. POAG patients underwent Goldmann tonometry, slit lamp biomicroscopy of the optic discs, Humphrey full threshold 24: 2 visual fields, and four mirror gonioscopy. Controls underwent the same examination, omitting gonioscopy and substituting suprathreshold fields for full threshold fields.