Recent Advances in Thiol and Sulfide Reactive Probes
Recent Advances in Thiol and Sulfide Reactive Probes
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DOI：
10.1002/jcb.24762
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发表时间：
2014-06-01
影响因子：
4
通讯作者：
Wang, Binghe
中科院分区：
文献类型：
--
作者：
Wang, Ke;Peng, Hanjing;Wang, Binghe
由于巯基和硫化物（如半胱氨酸、同型半胱氨酸、谷胱甘肽和硫化氢）的生物学相关性，它们的检测引起了极大的研究兴趣。荧光探针由于其高灵敏度、低成本以及能够检测和成像生物样品中的硫醇而成为硫醇和硫化氢分析的新策略。本文综述了硫醇和硫化氢反应性荧光探针的最新研究进展。这些探针在设计策略、机制、光物理性质和/或反应动力学方面进行了比较和对比。并讨论了这些探针的生物学应用。j .细胞。中国生物医学工程学报，2014,31(2):444 - 444。(c) 2013 Wiley Periodicals, Inc.；
Because of the biological relevance of thiols and sulfides such as cysteine, homocysteine, glutathione and hydrogen sulfide, their detection has attracted a great deal of research interest. Fluorescent probes are emerging as a new strategy for thiol and hydrogen sulfide analysis due to their high sensitivity, low cost, and ability to detect and image thiols in biological samples. In this short review, we have summarized recent advances in the development of thiol and hydrogen sulfide reactive fluorescent probes. These probes are compared and contrasted with regard to their designing strategies, mechanisms, photophysical properties, and/or reaction kinetics. Biological applications of these probes are also discussed. J. Cell. Biochem. 115: 1007-1022, 2014. (c) 2013 Wiley Periodicals, Inc.