Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
Sulforaphane and Other Nutrigenomic Nrf2 Activators: Can the Clinician's Expectation Be Matched by the Reality?
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DOI：
10.1155/2016/7857186
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发表时间：
2016
影响因子：
--
通讯作者：
Coombes JS
中科院分区：
文献类型：
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作者：
Houghton CA;Fassett RG;Coombes JS
食物来源的非营养分子可以调节基因表达，影响细胞内的分子机制的认识已经看到了营养基因组学和营养遗传学领域的出现。本综述的目的是描述转录因子Nrf2（核因子红细胞2相关因子2）的营养基因组激活剂的特性，比较萝卜硫素和其他植物化学物质的潜力，以证明作为补充药物的临床疗效。西兰花衍生的萝卜硫素作为具有这种能力的植物化学物质出现，口服剂量能够有利地修饰与化学预防相关的基因。与广泛使用的基于植物化学物质的补充剂（如姜黄素、水飞蓟素和白藜芦醇）相比，萝卜硫素更有效地激活Nrf 2以诱导一系列细胞保护基因的表达。由于其亲脂性和低分子量，萝卜硫素显示出比也激活Nrf2的基于多酚的膳食补充剂显著更高的生物利用度。Nrf2激活诱导细胞保护基因，如在细胞防御机制中发挥关键作用的基因，包括氧化还原状态和解毒。其高生物利用度和显著的Nrf2诱导剂能力有助于产生莱菔硫烷的补充剂的治疗潜力。
The recognition that food-derived nonnutrient molecules can modulate gene expression to influence intracellular molecular mechanisms has seen the emergence of the fields of nutrigenomics and nutrigenetics. The aim of this review is to describe the properties of nutrigenomic activators of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), comparing the potential for sulforaphane and other phytochemicals to demonstrate clinical efficacy as complementary medicines. Broccoli-derived sulforaphane emerges as a phytochemical with this capability, with oral doses capable of favourably modifying genes associated with chemoprevention. Compared with widely used phytochemical-based supplements like curcumin, silymarin, and resveratrol, sulforaphane more potently activates Nrf2 to induce the expression of a battery of cytoprotective genes. By virtue of its lipophilic nature and low molecular weight, sulforaphane displays significantly higher bioavailability than the polyphenol-based dietary supplements that also activate Nrf2. Nrf2 activation induces cytoprotective genes such as those playing key roles in cellular defense mechanisms including redox status and detoxification. Both its high bioavailability and significant Nrf2 inducer capacity contribute to the therapeutic potential of sulforaphane-yielding supplements.