The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse
The effects of Liuwei Dihuang decoction on the gene expression in the hippocampus of senescence-accelerated mouse
复制标题
DOI：
10.1016/j.fitote.2006.11.006
复制
发表时间：
2007-04-01
期刊：
影响因子：
3.4
通讯作者：
Zhang, Yong-Xiang
中科院分区：
文献类型：
--
作者：
Cheng, Xiao-Rui;Zhou, Wen-Xia;Zhang, Yong-Xiang
六味地尔芒汤是一种传统的中药方剂，它通过对中枢神经系统某些基因表达的显著调节作用而增强中枢神经系统的认知功能。DUSP 12、NSF、STUB 1、CaMK Ⅱ α、AMFR、UQCRFS 1等11个无功能线索的新基因的表达发生了显著变化。这些基因涉及蛋白酪氨酸磷酸酶家族、AAA（ATPases associat，艾德with different cellular activities）基因家族、丝氨酸/苏氨酸蛋白激酶家族、泛素连接酶、线粒体功能等。（C）2007 Elsevier B. V.版权所有。
Liuwei Dilmang decoction (LW), a traditional Chinese medicinal prescription, enhances the cognitive function of CNS by significant modulating effects on some of the gene expressions. Expressions of genes, such as DUSP12, NSF, STUB1, CaMKII alpha, AMFR, UQCRFS1 and other 11 novel genes without any functional clues changed significantly. These genes are involved in the protein-tyrosine phosphatase family, the AAA (ATPases associat,ed with diverse cellular activities) gene family, the serine/threonine protein kinases family, ubiquitin ligase, mitochondrial function and so on. (C) 2007 Elsevier B.V. All rights reserved.