Cardiovascular development and survival during gestation in the Ts65Dn mouse model for Down syndrome.
Cardiovascular development and survival during gestation in the Ts65Dn mouse model for Down syndrome.
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唐氏综合症 Ts65Dn 小鼠模型妊娠期间的心血管发育和存活。
DOI：
10.1002/ar.21301
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Moore,ClaraS
中科院分区：
文献类型：
--
作者：
Lorandeau,CandiceG;Hakkinen,LaurenA;Moore,ClaraS
The Ts65Dn mouse model for Down syndrome (DS) exhibits many phenotypes seen in human DS. Previous research has revealed a reduced rate of transmission of the T65Dn marker chromosome in neonates. To analyze potential fetal loss, litters from trisomic females at 10.5dpc through 14.5dpc were genotyped. No significant differences from the expected Mendelian ratio were found in transmission of T65Dn at any stage. Cardiovascular defects found in trisomic neonates are associated with formation of pharyngeal arch arteries. Vessel tracing was used to identify anomalies in 10.5dpc, 11.5dpc, and 13.5dpc embryos. Comparison of trisomic versus euploid embryos injected with India ink revealed delay and abnormality in cardiovascular development in trisomic embryos at each stage. Through the analysis of transmission rate and cardiovascular development in embryonic mice, we learn more about prenatal mortality and the origins of cardiac abnormality in the Ts65Dn mice to assist in understanding cardiovascular malformation associated with DS. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
