THE BEHAVIOUR OF CHROMATOLYSED MOTONEURONES STUDIED BY INTRACELLULAR RECORDING
THE BEHAVIOUR OF CHROMATOLYSED MOTONEURONES STUDIED BY INTRACELLULAR RECORDING
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DOI：
10.1113/jphysiol.1958.sp006041
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发表时间：
1958-01-01
影响因子：
5.5
通讯作者：
YOUNG, RR
中科院分区：
文献类型：
--
作者：
ECCLES, JC;LIBET, B;YOUNG, RR
采用细胞内记录的方法，研究了猫在适当的腹根外切后14 ~ 44天的色素溶解运动神经元的反应。在静息电位、尖峰电位和后电位方面，染色化运动神经元与正常运动神经元没有显著差异。主要的异常表现在由兴奋性突触作用（EPSP）产生的电位和由运动神经元发起的脉冲的方式有关。在染色质分解的运动神经元中，单突触EPSP在大小和时间上明显减小，并在其上叠加各种驼峰状的去极化，这些去极化随着脉冲沿运动轴突放电而过渡到产生全尺寸脉冲。运动神经元的超极化可逆地抑制或消除这些驼峰。因此，这些突起可归因于小块的躯体-树突膜的反应，或者是限制在远处树突区域的全尺寸脉冲。相对于体树突尖峰，向染色质化运动神经元初始段的反向繁殖安全系数较低，且其尖峰电位较小。这些异常解释了I组传入齐射引起的反射放电的较长潜伏期和大大增加的时间弥散性。讨论了对运动神经元整合连接的不利影响。
The responses of chromatolyzed motoneurones of cats were studied by intra-cellular recording from 14 to 44 days after the appropriate ventral roots were severed extradurally. Chromatolyzed motoneurones do not signifi-cantly differ from normal motoneurones in respect to resting, spike or after potentials. The principal abnormalities appear in relation to the potentials which are generated by excitatory synaptic action (the EPSP''s) and in the manner of initiation of impulses by the motoneurone. In chromatolyzed motoneurones, the monosynaptic EPSP''s are significantly reduced in size and in time to summit, and superimposed upon them are a variety of hump-like depolarizations which are transitional to the generation of full-size impulses with the discharge of impulses down the motor axons. Hyperpolarization of a motoneurone reversibly depresses or abolishes these humps. The humps are consequently attributed to responses of patches of the soma-dendritic membrane or to full-size impulses restricted to remote dendritic areas. Antidromic propagation into the initial segment of chromatolyzed motoneurones has a lowered safety factor and its spike potential is small relative to the somatodendritic spike. These abnormalities account for the longer latency and greatly increased temporal dispersion of the reflex discharge evoked by a group I afferent volley. The unfavorable effect on the integrative Junction of the motoneurone is discussed.