Health-Related Quality of Life in Adolescent and Young Adult Patients With Cancer: A Longitudinal Study
Health-Related Quality of Life in Adolescent and Young Adult Patients With Cancer: A Longitudinal Study
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DOI：
10.1200/jco.2016.69.7946
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发表时间：
2017-02-01
影响因子：
45.3
通讯作者：
Cole, Steve
中科院分区：
文献类型：
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作者：
Husson, Olga;Zebrack, Brad J.;Cole, Steve
PurposeTo检查的变化与健康有关的生活质量（HRQoL）和其预测因素在最初的2年后，在最初的癌症诊断在青少年和年轻的成年人（AYA）patientswith cancer.Patients和MethodsA多中心，纵向，前瞻性研究进行了不同的样本AYA患者癌症年龄15至39岁。176例患者（75%应答）在诊断后前4个月内以及12个月和24个月后再次完成HRQoL自我报告测量（简表-36 [SF-36]）。与随机截距和斜率估计QoL.ResultsRecently诊断的AYA癌症患者的变化线性混合模型有显着较差的身体成分量表（PCS）评分（38.7 v 52.8; P < .001）和心理成分量表（MCS）评分（42.9 v 48.9; P < .001）相比，人口规范。观察到PCS和MCS评分从基线到24个月随访的显著改善;然而，这些增加在前12个月内最大。在24个月的随访中，AYA患者的PCS评分（48.0 v52.8; P <0.001）和MCS评分（45.8 v48.9; P = 0.002）仍显著低于人群标准。多变量分析显示，PCS和MCS评分的改善主要是停止治疗和参与学校或工作的函数。PCS，但不是MCS评分更糟的AYA患者诊断为癌症与贫困prosecses.ConclusionAlthough HRQoL随着时间的推移改善，它仍然是妥协后24个月的初步诊断。鉴于在诊断后12至24个月期间观察到HRQoL的改善相对较少，AYA患者可能会从诊断后第二年的支持性护理干预中获益。(C)2017年美国临床肿瘤学会
PurposeTo examine changes in health-related quality of life (HRQoL) and its predictors during the first 2 years after initial cancer diagnosis in adolescent and young adult (AYA) patients with cancer.Patients and MethodsA multicenter, longitudinal, prospective study was conducted among a diverse sample of AYA patients with cancer ages 15 to 39 years. One hundred seventy-six patients (75% response) completed a self-report measure of HRQoL (Short Form-36 [SF-36]) within the first 4 months after diagnosis and again 12 and 24 months later. Linear mixed models with random intercepts and slopes estimated changes in QoL.ResultsRecently diagnosed AYA patients with cancer had significantly worse physical component scale (PCS) scores (38.7 v 52.8; P < .001) and mental component scale (MCS) scores (42.9 v 48.9; P < .001) when compared with population norms. Significant improvements in PCS and MCS scores from baseline to 24-month follow-up were observed; however, these increases were largest during the first 12 months. At the 24-month follow-up, AYA patients still had significantly lower PCS scores (48.0 v 52.8; P < .001) and MCS scores (45.8 v 48.9; P = .002) when compared with population norms. Multivariable analyses revealed that improvements in PCS and MCS scores were primarily a function of being off-treatment and being involved in school or work. PCS but not MCS scores were worse for AYA patients diagnosed with cancers with poorer prognoses.ConclusionAlthough HRQoL improved over time, it was still compromised 24 months after primary diagnosis. Given relatively little observed improvement in HRQoL during the 12- to 24-month period after diagnosis, AYA patients may benefit from supportive care interventions administered during the second year after diagnosis. (C) 2017 by American Society of Clinical Oncology