Rat strain differences in nicotine self-administration using an unlimited access paradigm
Rat strain differences in nicotine self-administration using an unlimited access paradigm
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DOI：
10.1016/s0006-8993(01)03375-3
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发表时间：
2002-03-15
期刊：
影响因子：
2.9
通讯作者：
Sharp, BM
中科院分区：
文献类型：
--
作者：
Brower, VG;Fu, YT;Sharp, BM
一个有效的动物模型来阐明人类吸烟的神经生物学基础，应该模拟这种行为的重要方面。因此，使用23 h无限制尼古丁自我给药模型比较了具有自我给药滥用药物倾向的近交系刘易斯大鼠与近交系Fisher 344大鼠和远系Holtzman品系。使用这种不受限制的进入模型，88.8%的刘易斯大鼠和57.1%的Holtzman大鼠在0.03 mg/kg IV尼古丁下以固定比率1（FR 1）实现了维持自我给药（P
An effective animal model for elucidating the neurobiological basis of human smoking should simulate important aspects of this behavior. Therefore, a 23 h unlimited access nicotine self-administration model was used to compare inbred Lewis rats, which have a propensity to self-administer drugs of abuse, to inbred Fisher 344 rats and to the outbred Holtzman strain. Using this unlimited access model, 88.8% of Lewis vs. 57.1% of Holtzman rats achieved maintenance self-administration at a fixed ratio 1 (FR 1) at 0.03 mg/kg IV nicotine (P