Pharmacokinetics of high-dose etoposide.
Pharmacokinetics of high-dose etoposide.
复制标题
大剂量依托泊苷的药代动力学。
DOI：
10.1038/clpt.1988.73
复制
发表时间：
1988
影响因子：
6.7
通讯作者：
Blume,KG
中科院分区：
文献类型：
--
作者：
Newman,EM;Doroshow,JH;Forman,SJ;Blume,KG
本文研究了恶性血液病患者口服足叶乙甙1 ~ 3 gm/m2的药代动力学。非房室系统清除率、平均滞留时间、稳态分布容积和消除半衰期与依托泊苷剂量无关，而AUC与剂量成比例。这些结果与以前报道的结果比较表明，依托泊苷在30倍剂量范围内（0.1 - 3 gm/m2）表现出线性药代动力学（Clinical Pharmacology and Therapeutics（1988）43，561 -564; doi：10.1038/clpt.1988.73
The pharmacokinetics of etoposide at doses of 1 gm/m2to 3 gm/m2were studied in patients with hematologic malignancies. The noncompartmental systemic clearance, mean residence time, steady‐state volume of distribution, and elimination half‐life were independent of the dose of etoposide, whereas the AUC was proportional to the dose. Comparison of these results with those reported previously indicates that etoposide exhibits linear pharmacokinetics over a thirtyfold range in doses (0.1 to 3 gm/m2).Clinical Pharmacology and Therapeutics(1988)43,561–564; doi:10.1038/clpt.1988.73