Sarcopenia Is Associated with Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)
Sarcopenia Is Associated with Cognitive Impairment Mainly Due to Slow Gait Speed: Results from the Korean Frailty and Aging Cohort Study (KFACS)
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DOI：
10.3390/ijerph16091491
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发表时间：
2019-05-01
影响因子：
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通讯作者：
Won, Chang Won
中科院分区：
文献类型：
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作者：
Kim, Miji;Won, Chang Won
肌肉减少症和认知障碍可能有共同的危险因素和病理生理途径。我们研究了特定认知领域的障碍与社区老年人肌肉减少症（及其定义成分）之间的关联。我们分析了1887例接受认知功能测试和双能X线骨密度仪的患者，这些患者的基线数据来自韩国虚弱和老龄化队列研究中70-84岁的成年人。排除了日常生活活动障碍、痴呆、严重认知障碍、帕金森病、肌肉骨骼疾病、神经系统疾病或文盲。认知功能的评估使用韩国版本的联盟建立一个登记阿尔茨海默病评估包，正面评估电池。对于肌肉减少症，我们使用亚洲肌肉减少症工作组的诊断标准。男性肌肉减少症的患病率为9.6%，女性为7.6%。肌肉减少症（比值比[OR] 1.76，95%置信区间[CI] 1.04-2.99）和缓慢步态速度（OR 2.58，95% CI 1.34-4.99）与男性认知功能障碍相关。只有缓慢的步态速度（OR 1.88，95%CI 1.05-3.36）与女性认知障碍相关。肌肉减少症与认知障碍有关，主要是由于步态速度慢。我们的研究结果表明，认知障碍领域，如处理速度和执行功能，与肌肉减少症相关的缓慢步态速度。
Sarcopenia and cognitive impairment may share common risk factors and pathophysiological pathways. We examined the association between impairments in specific cognitive domains and sarcopenia (and its defining components) in community-dwelling older adults. We analyzed 1887 patients who underwent cognitive function tests and dual-energy X-ray absorptiometry from the baseline data of adults aged 70-84 years obtained from the Korean Frailty and Aging Cohort Study. Those with disability in activities of daily living, dementia, severe cognitive impairment, Parkinson's disease, musculoskeletal complaints, neurological disorders, or who were illiterate were excluded. Cognitive function was assessed using the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet, the Frontal Assessment Battery. For sarcopenia, we used the diagnostic criteria of the Asian Working Group for Sarcopenia. The prevalence of sarcopenia was 9.6% for men and 7.6% for women. Sarcopenia (odds ratio [OR] 1.76, 95% confidence interval [CI] 1.04-2.99) and slow gait speed (OR 2.58, 95% CI 1.34-4.99) were associated with cognitive impairment in men. Only slow gait speed (OR 1.88, 95% CI 1.05-3.36) was associated with cognitive impairment in women. Sarcopenia is associated with cognitive impairment mainly due to slow gait speed. Our results suggested that cognitive impairment domains, such as processing speed and executive function, are associated with sarcopenia-related slow gait speed.