Patient-specific mechanical analysis of PCL periodontal membrane: Modeling and simulation
Patient-specific mechanical analysis of PCL periodontal membrane: Modeling and simulation
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PCL 牙周膜的患者特异性力学分析：建模和模拟
DOI：
10.1016/j.jmbbm.2024.106397
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发表时间：
2024
影响因子：
3.9
通讯作者：
Thomas, Vinoy
中科院分区：
文献类型：
--
作者：
Pemmada, Rakesh;Telang, Vicky Subhash;Tandon, Puneet;Thomas, Vinoy
这项研究填补了骨组织工程领域的一项知识空白，它利用一项尖端技术，利用聚己内酯(PCL)创建3D支架，来检测骨-组织界面上支架的力学特性。采用有限元分析方法对支架的最大主应力和等效应力应变进行了测量。对上颌骨和下颌骨进行CT扫描，将载荷条件应用于上中切牙的3D模型。在所建立的计算模型中，考虑了四种不同的载荷情况：咀嚼载荷(在45°时为70-100nN)、两种副功能习惯(100-130nN)和切缘500-550nN(均为45°)，以及一种创伤情况(800-850nN在90°时从内向垂直施加)。研究结果表明，中心牙区的应力集中程度最高，而上颌和下颌区的应力最小。这些结果为骨-组织界面上支架的力学行为提供了重要的见解，为开发接近真实骨特征的支架提供了一个研究方向。这项研究的结果对于使用骨替代材料具有特别重要的意义，为骨创伤和退行性骨疾病提供了一种更有效的愈合选择。
This research fills a knowledge gap in bone tissue engineering by examining the mechanical characteristics of scaffolds at bone-tissue interfaces utilizing a cutting-edge technique involving the creation of 3D scaffolds from Polycaprolactone (PCL). The work employs Finite element analysis to measure the scaffolds' maximum principal and Von Mises stresses and strains. CT scans of the Maxilla and Mandible were used to apply load conditions to 3D models of the upper central incisor. In the derived computational model, four different load situations considered were: the masticatory load (70–100 N at 45°), two parafunctional habits (100–130 N) and 500–550 N at the incisal edge, both at 45°), and a trauma case (800–850 N applied perpendicularly from the inwards direction at 90°). The findings revealed that the central tooth region experiences the highest stress concentration, while the Maxilla and Mandible regions show the least stress. These results provide critical insights into the mechanical behavior of scaffolds at bone-tissue interfaces, suggesting a research direction for developing scaffolds that closely mimic real bone characteristics. The results of this study are particularly significant for using bone replacement materials, providing an approach to more effective healing options for bone traumas and degenerative bone disorders.