Role of ions in generation of taste nerve responses to electrical tongue stimulation in rats.
Role of ions in generation of taste nerve responses to electrical tongue stimulation in rats.
复制标题
离子在大鼠对电舌刺激产生味觉神经反应中的作用。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
M. Funakoshi
中科院分区：
文献类型：
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作者：
Y. Ninomiya;M. Funakoshi
通过检测大鼠鼓索神经对化学和电刺激舌的综合反应和单纤维放电，研究了离子在产生味觉神经对电流的反应中的作用。综合鼓索阳极电流的反应被抑制后，停止血液流向舌头和FeCl3的应用程序的舌头表面。这些发现表明，电流并不直接刺激神经，而是激活味觉细胞引起神经放电。对阳极电流的综合反应的幅度随着浓度的降低和在电刺激期间施加在舌头上的沐浴溶液的流速的增加而降低。所有的鼓索纤维响应于一定的电解质响应于阳极或阴极电流中存在的相同的电解质在其阈下浓度的流动室。然而，有一些纤维不响应于一些电解质，但响应于电流中的任一种电解质的存在下，即使在其低得多的浓度。跨纤维的化学刺激和阳极电流的存在下，在流动室中的化学溶液的反应之间的相关性表明，阳极电流的反应并不总是依赖于在洗浴液中的阳离子的种类。根据这些发现，我们假设对电流的响应是由于电迁移携带的离子不仅对离子的特异性而且对非特异性受体机制的影响。
The role of ions in the generation of taste nerve responses to electric currents was studied by examining integrated responses and single fiber discharges of the chorda tympani nerve to chemical and electrical stimulations of the tongue in rats. Integrated chorda tympani responses to anodal currents were suppressed after cessation of the blood flow to the tongue and on application of FeCl3 to the tongue surface. These findings indicate that electric currents do not stimulate the nerve directly but activate taste cells to evoke neural discharges. Magnitude of the integrated response to anodal current decreased with a decrease in concentration and with an increase in flow rate of the bathing solution applied over the tongue during electrical stimulation. All the chorda tympani fibers responsive to a certain electrolyte responded to anodal or cathodal current in the presence of the same electrolyte at its subliminal concentration in the flow chamber. However, there were a few fibers which did not respond to a few electrolytes, but responded to currents in the presence of either one of the electrolytes even at their much lower concentrations. Across-fiber correlations between the responses to chemical stimuli and anodal currents in the presence of the chemical solutions in the flow chamber indicated that responsiveness to anodal current was not always dependent on species of cation in the bathing solution. From these findings, we assume that the response to electric current is due to the effect of electrophoretically carried ions on not only specific but also non-specific receptor mechanisms for the ions.