Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
Influence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
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DOI：
10.1016/j.bbr.2010.01.021
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发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Pertovaara, Antti
中科院分区：
文献类型：
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作者：
Ansah, Osei B.;Bourbia, Nora;Pertovaara, Antti
通过评估神经损伤动物在杏仁核给予各种谷氨酸能化合物后单药诱导的肢体退缩反应（感觉疼痛）和厌恶性位置条件反射行为（情绪疼痛），研究了杏仁核谷氨酸能受体（GluRs）在维持神经病理性疼痛的感觉与情绪成分中的作用。结果表明，杏仁核I组代谢型GluR、mGluR（1）和mGluR（5）以及NMDA-R的内源性激活有助于维持神经病理性疼痛的感觉和情感成分。杏仁核I组mGluRs的主要作用是促进情感样疼痛行为。(C)2010 Elsevier B. V.保留所有权利。
The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior. (C) 2010 Elsevier B.V. All rights reserved.