Effect of age on bronchial reactivity in children with asthma
Effect of age on bronchial reactivity in children with asthma
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DOI：
10.1080/02770900500446948
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发表时间：
2006-01-01
影响因子：
1.9
通讯作者：
Morikawa, A
中科院分区：
文献类型：
--
作者：
Mochizuki, H;Arakawa, H;Morikawa, A
与大量关于年龄相关的支气管敏感性变化的数据相反，年龄与支气管收缩（支气管反应性）的快速性之间的关系尚不清楚。我们研究了哮喘儿童的年龄和支气管反应性。本研究入组了511名哮喘受试者和115名年龄匹配的对照受试者，年龄为1至16岁。支气管反应性由年龄较小儿童的乙酰甲胆碱经皮氧压剂量-反应曲线（SPO 2）的斜率和年龄较大儿童的呼吸阻力剂量-反应曲线（SRrs）的斜率表示。哮喘组的SPO 2和SRrs均高于对照组。在哮喘受试者中，SPO 2从1岁到6岁显著增加，7岁后达到平台期。在对照组中也观察到这种年龄相关的SPO 2变化。哮喘受试者的SRrs在13岁后下降，而对照组的SRrs在7岁至16岁之间没有显着变化。哮喘相关的支气管反应性变化发生在儿童时期，可能反映了气道平滑肌成熟的早期变化和气道壁硬度的后期变化。
In contrast to an abundance of data concerning age-related changes of bronchial sensitivity, the relationship between age and rapidity of bronchoconstriction (bronchial reactivity) remains unclear. We studied age and bronchial reactivity in children with asthma. Enrolled in this study were 511 asthmatic subjects and 115 age-matched control subjects 1 to 16 years of age. Bronchial reactivity was represented by the slope of the methacholine transcutaneous oxygen pressure dose-response curve (SPO 2 ) in younger children and the slope of the respiratory resistance dose-response curve (SRrs) in older children. Overall, SPO 2 and SRrs were higher in asthmatic than control subjects. SPO 2 increased significantly from 1 to 6 years in asthmatic subjects, reaching a plateau after age 7. This age-related change in SPO 2 also was seen in controls. SRrs in asthmatic subjects decreased after age 13, while SRrs in controls showed no significant change between age 7 and 16. Age-related change in bronchial reactivity occurs during childhood, possibly reflecting early changes in airway smooth muscle maturity and later changes in airway wall rigidity.