Prefrontal-Amygdala Connectivity and State Anxiety during Fear Extinction Recall in Adolescents
Prefrontal-Amygdala Connectivity and State Anxiety during Fear Extinction Recall in Adolescents
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DOI：
10.3389/fnhum.2017.00587
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发表时间：
2017-12-04
影响因子：
2.9
通讯作者：
Whittle, Sarah
中科院分区：
文献类型：
--
作者：
Ganella, Despina E.;Barendse, Marjolein E. A.;Whittle, Sarah
虽然恐惧消退回忆的缺陷已被认为是青少年易患焦虑症的基础，但这些缺陷的神经生物学仍有待研究。在这里，我们调查的功能连接（FC）的腹内侧前额叶皮层（vmPFC）和背外侧PFC（dlPFC）的基础上灭绝回忆在健康的青少年，并评估FC和状态/特质焦虑之间的关联。青少年（17）和成年人（14，作为比较）完成了一个恐惧学习范式，涉及灭绝和灭绝回忆在功能性磁共振成像会议，其中皮肤电导反应（SCR）被记录。心理生理相互作用分析表明，在灭绝回忆有显着的负连接之间的VMPFC和杏仁核的成年人，但不是青少年。VMPFC-杏仁核连接与SCR呈正相关。青少年的背外侧前额叶皮层与左右海马、杏仁核之间的FC呈显著负相关，与状态焦虑呈正相关。青少年的回忆还与dlPFC与丘脑、后扣带回皮质、梭状回和苍白球之间的负连接有关。这些结果表明，健康青少年的恐惧消退回忆与前额叶和边缘脑区域之间的FC有关，并表明连接的改变可能与青春期焦虑的脆弱性有关。
While deficits in fear extinction recall have been suggested to underlie vulnerability to anxiety disorders in adolescents, the neurobiology of these deficits remain underexplored. Here we investigate the functional connectivity (FC) of the ventromedial prefrontal cortex (vmPFC) and dorsolateral PFC (dlPFC) underlying extinction recall in healthy adolescents, and assess associations between FC and state/trait anxiety. Adolescents (17) and adults (14, for comparison) completed a fear-learning paradigm involving extinction and extinction recall during a functional magnetic resonance imaging session, in which skin conductance response (SCR) was recorded. Psychophysiological interaction analyses revealed that during extinction recall there was significant negative connectivity between the vmPFC and amygdala in adults, but not adolescents. vmPFC-amygdala connectivity was positively correlated with SCR. Adolescents showed significant negative FC between the dlPFC and the left and right hippocampus, and the amygdala, which was positively correlated with state anxiety. Recall was also associated with negative connectivity between the dlPFC and thalamus, posterior cingulate cortex, fusiform gyrus, and pallidum in adolescents. These results demonstrate that fear extinction recall in healthy adolescents is associated with FC between prefrontal and limbic brain regions, and suggest that alterations in connectivity may be associated with vulnerability to anxiety in adolescence.