Cloning and genomic organization of the human transforming growth factor-beta type I receptor gene.
Cloning and genomic organization of the human transforming growth factor-beta type I receptor gene.
复制标题
人类转化生长因子-β I 型受体基因的克隆和基因组组织。
DOI：
10.1006/geno.1997.5023
复制
发表时间：
1997
期刊：
影响因子：
4.4
通讯作者：
Reiss,M
中科院分区：
文献类型：
--
作者：
Vellucci,VF;Reiss,M
转化生长因子-β (TGFβ) 通过独特的信号传导机制调节细胞周期进程，该机制涉及其与 II 型 (TβR-II) TGFβ 受体的结合以及 I 型 (TβR-I) 的激活。两者都是跨膜丝氨酸-苏氨酸受体激酶。由于各种类型的人类肿瘤细胞通常难以抵抗 TGFβ 介导的细胞周期停滞，因此在许多情况下 TβR-I 受体很可能失活。我们确定了 TGFBR1 基因的内含子-外显子组织。我们在此报告该基因长度约为 31 kb，由 9 个外显子组成。编码丝氨酸-苏氨酸激酶结构域的C-末端部分的TGFBR1基因片段的组织在R-I基因家族的成员之间似乎是高度保守的。这些信息应该有助于并加速人类肿瘤和可能的其他疾病状态中 TGFBR1 的结构分析。
Transforming growth factor-β (TGFβ) regulates cell cycle progression by a unique signaling mechanism that involves its binding to the type II (TβR-II) TGFβ receptor and activation of type I (TβR-I). Both are transmembrane serine-threonine receptor kinases. As various types of human tumor cells are often refractory to TGFβ-mediated cell cycle arrest, it is likely that the TβR-I receptor is inactivated in many of these cases. We determined the intron–exon organization of theTGFBR1gene. We report here that this gene is approximately 31 kb in length and consists of nine exons. The organization of the segment of theTGFBR1gene that encodes the C-terminal portion of the serine-threonine kinase domain appears to be highly conserved between members of the R-I gene family. This information should facilitate and expedite the structural analysis ofTGFBR1in human tumors and possibly other disease states.