Trends in the application of high-resolution mass spectrometry for human biomonitoring: An analytical primer to studying the environmental chemical space of the human exposome.
Trends in the application of high-resolution mass spectrometry for human biomonitoring: An analytical primer to studying the environmental chemical space of the human exposome.
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DOI：
10.1016/j.envint.2016.11.026
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发表时间：
2017-03
影响因子：
11.8
通讯作者：
Arora M
中科院分区：
文献类型：
--
作者：
Andra SS;Austin C;Patel D;Dolios G;Awawda M;Arora M
在非靶向模式下对人类基质中的外源性物质进行全球分析，正日益受到人们的关注，以研究人类肿瘤组的环境化学空间。人类代谢组学是对环境影响和相关生物反应的综合研究，目前正在从代谢组学中发展出来。与后者类似，高分辨率质谱（HRMS）的发展和应用已经显示出极大的潜力和前景，大大扩展了我们在复杂研究中捕获广谱环境化学品的能力。HRMS可以进行非靶向和靶向分析，因为它能够以高质量精度和良好的灵敏度进行全质谱和/或串联质谱采集。从目标、可疑和非目标筛选中收集的数据不仅可用于前瞻性地识别人体基质中的环境化学污染物，而且可用于回顾性地识别。本文综述了这一领域的最新趋势和进展。我们专注于HRMS在人体生物监测研究，数据采集和挖掘方面的进展和应用。所获得的见解提供了垫脚石，以提高对人类麻烦的理解，通过应用人力资源管理系统，以及未来研究的挑战和前景。
Global profiling of xenobiotics in human matrices in an untargeted mode is gaining attention for studying the environmental chemical space of the human exposome. Defined as the study of a comprehensive inclusion of environmental influences and associated biological responses, human exposome science is currently evolving out of the metabolomics science. In analogy to the latter, the development and applications of high resolution mass spectrometry (HRMS) has shown potential and promise to greatly expand our ability to capture the broad spectrum of environmental chemicals in exposome studies. HRMS can perform both untargeted and targeted analysis because of its capability of full- and/or tandem-mass spectrum acquisition at high mass accuracy with good sensitivity. The collected data from target, suspect and non-target screening can be used not only for the identification of environmental chemical contaminants in human matrices prospectively but also retrospectively. This review covers recent trends and advances in this field. We focus on advances and applications of HRMS in human biomonitoring studies, and data acquisition and mining. The acquired insights provide stepping stones to improve understanding of the human exposome by applying HRMS, and the challenges and prospects for future research.