18F-FDG PET in the management of patients with anaplastic thyroid carcinoma
18F-FDG PET in the management of patients with anaplastic thyroid carcinoma
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DOI：
10.1089/thy.2007.0350
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发表时间：
2008-07-01
期刊：
影响因子：
6.6
通讯作者：
Lowe, Val J.
中科院分区：
文献类型：
--
作者：
Bogsrud, Trond Velde;Karantanis, Dimitrios;Lowe, Val J.
背景：甲状腺未分化癌（ATC）是人类最具侵袭性的实体肿瘤之一。使用正电子发射断层扫描（PET）与F-18-氟脱氧葡萄糖（F-18-FDG）在ATC尚未研究，只有少数病例报告已发表。本研究的目的是调查的潜在贡献F-18-FDG PET与ATC patients.Methods的临床管理的所有ATC患者与F-18-FDG PET研究从2001年8月至2007年3月。PET结果与计算机断层扫描、超声、磁共振成像、骨扫描、组织学和临床随访相关。FDG摄取半定量为最大标准摄取值。在治疗计划中的任何变化，作为一个直接结果的PET结果记录在临床notes.Results：16例患者被列入。在所有原发性肿瘤、所有9例淋巴结转移患者、8例肺转移患者中的5例和2例肺转移以外的远处转移患者中均观察到真阳性PET结果。在16例患者中的8例，医疗记录报告的PET结果对临床management.Conclusions的直接影响：ATC表现出强烈的摄取F-18-FDG PET图像。在16例患者中的8例（50%）中，病历报告PET结果对患者管理有直接影响。相对于其他成像方式，PET可以改善疾病检测，并对ATC患者的管理产生影响。
Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors in humans. The use of positron emission tomography (PET) with F-18-fluorodeoxyglucose (F-18-FDG) in ATC has not been studied, and only a few case reports have been published. The objective of this study was to investigate the potential contribution of F-18-FDG PET to the clinical management of patients with ATC.Methods: All patients with ATC studied with F-18-FDG PET from August 2001 through March 2007 were included. The PET results were correlated with computed tomography, ultrasound, magnetic resonance imaging, bone scan, histology, and clinical follow-up. The FDG uptake was semiquantified as maximum standard uptake value. Any change in the treatment plan as a direct result of the PET findings as documented in the clinical notes was recorded.Results: Sixteen patients were included. True-positive PET findings were seen for all primary tumors, in all nine patients with lymph node metastases, in five out of eight patients with lung metastases, and in two patients with distant metastases other than lung metastases. In 8 of the 16 patients, the medical records reported a direct impact of the PET findings on the clinical management.Conclusions: ATC demonstrates intense uptake on F-18-FDG PET images. In 8 of the 16 patients (50%), the medical records reported a direct impact of the PET findings on the management of the patient. PET may improve disease detection and have an impact on the management of patients with ATC relative to other imaging modalities.