Two New Alkaloids from Brachystemma calycinum and Their Inhibitory Effects on Lymphocyte Proliferation
Two New Alkaloids from Brachystemma calycinum and Their Inhibitory Effects on Lymphocyte Proliferation
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DOI：
10.1002/cbdv.200790244
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发表时间：
2007-12
影响因子：
2.9
通讯作者：
Qing Lu;Li Zhang;G. He;Heng-xing Liang;G. Du;Yong‐Xian Cheng
中科院分区：
文献类型：
--
作者：
Qing Lu;Li Zhang;G. He;Heng-xing Liang;G. Du;Yong‐Xian Cheng
Two new alkaloids, brachystemidines F (1) and G (2), were isolated from the roots of Brachystemma calycinum. Their structures were established on the basis of detailed spectroscopic analyses, including extensive NMR and HR‐MS techniques. Compound 2, which exhibits an unusual N‐hydroxydiazenyl (HONN) moiety, is a potent immunosuppressive agent, as demonstrated by inhibition of mouse T‐ and B‐lymphocyte proliferation, with IC50 values of 6.33 and 5.60 μg/ml, resp.
