[Paget's bone disease and virus (author's transl)].
[Paget's bone disease and virus (author's transl)].
复制标题
[佩吉特骨病和病毒（作者翻译）]。
作者：
A. Rebel;M. Baslé
尽管提出了大量的理论来阐明佩吉特病的病因，但其病因仍在讨论中，尚未得出令人满意的结论。1974年，在受影响的骨组织中的破骨细胞的细胞核和细胞质中发现了包涵体，这一发现提高了病毒起源的可能性。事实上，许多作者所描述的微圆柱结构，只有在破骨细胞和佩吉特病中才能看到，如果不包括某些巨细胞骨肿瘤的话，在形态学上与麻疹组副粘病毒的核衣壳非常相似，在实验感染或人类疾病（亚急性硬化性全脑炎）中也有描述。从佩吉特病中发现的富含核的巨大破骨细胞中的内含物的研究中得出的各种形态学论点都支持这些形成的病毒性质。免疫细胞学方法构成了另一种方法来解决发现内含物所提出的问题。他们已经证明在佩吉特病中发现的破骨细胞中存在抗原物质，该抗原物质与含有抗麻疹抗体的抗血清发生阳性反应或与它们产生交叉反应。对照试验证实了这些发现。因此，从世纪前首次描述的疾病的致病性假设中，目前生物学论据足以证明佩吉特病的病毒病因学可能性被有效地接受。
In spite of the large number of theories advanced to clarify the etiology of Paget's disease, its cause is still being discussed, and no satisfactory conclusion has been reached. The possibility of a viral origin was raised by the discovery of inclusion bodies, detectable by electron microscopy, in the nuclei and cytoplasm of the osteoclasts in the affected bone tissue, in 1974. In fact, the microcylindrical structures described by various authors, and visible only in osteoclasts and only in Paget's disease, if one excepts certain giant-cell bone tumors, have a close analogy, morphologically, with the nucleocapsids of paramyxovirus of the measles group, described in experimental infections or human diseases (subacute sclerosing panencephalitis). Various morphological arguments, drawn from studies of inclusions in richly nucleated giant osteoclasts found in Paget's disease, are in favor of the viral nature of these formations. Immunocytological methods have constituted another approach to the problem raised by the discovery of inclusions. They have demonstrated the existence of an antigenic material in the osteoclasts found in Paget's disease which reacts positively with antiserums containing anti-measles antibodies or with produce a crossed reaction with them. Controlled tests have confirmed these findings. Biological arguments are presently sufficient, therefore, for the possibility of a viral etiology of Paget's disease to be validly accepted from among the pathogenic hypotheses proposed for a disease that was first described a century ago.