Effects of insulin and streptozotocin-diabetes on isoproterenol-stimulated cyclic AMP production in myocytes isolated from rat heart.
Effects of insulin and streptozotocin-diabetes on isoproterenol-stimulated cyclic AMP production in myocytes isolated from rat heart.
复制标题
胰岛素和链脲佐菌素-糖尿病对异丙肾上腺素刺激的大鼠心脏分离的肌细胞中环磷酸腺苷产生的影响。
DOI：
10.1016/0026-0495(89)90246-1
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Misbin,RI
中科院分区：
文献类型：
--
作者：
Almira,EC;Misbin,RI
浓度高达10− 5 mol/L的异丙肾上腺素（ISO）可引起大鼠心肌细胞产生环腺苷酸（cAMP）的剂量依赖性刺激。在较高的ISO浓度下，观察到相对抑制。胰岛素增加ISO刺激的cAMP产生，并似乎减轻高ISO浓度的毒性作用。在心肌细胞中观察到的胰岛素和ISO之间的协同作用在脂肪细胞中没有观察到。链脲佐菌素（STZ）-糖尿病取消了胰岛素对ISO诱导的心肌细胞cAMP产生的刺激作用。
Isoproterenol (ISO), at concentrations of up to 10−5mol/L, caused a dose-dependent stimulation of cyclic AMP (cAMP) production in rat cardiomyocytes. At higher ISO concentrations, relative inhibition was seen. Insulin augmented ISO-stimulated cAMP production and appeared to mitigate the toxic effects of high ISO concentrations. This synergy between insulin and ISO observed in cardiomyocytes was not observed in adipocytes. Steptozotocin (STZ)-diabetes abolished the stimulatory effects of insulin on ISO-induced cAMP production in cardiomyocytes.