Periodontitis severity affects the clinical response to biological disease-modifying antirheumatic drugs in rheumatoid arthritis: A 1-year follow-up study
Periodontitis severity affects the clinical response to biological disease-modifying antirheumatic drugs in rheumatoid arthritis: A 1-year follow-up study
复制标题
牙周炎严重程度影响类风湿关节炎生物疾病缓解抗风湿药物的临床反应：一项为期一年的随访研究
DOI：
10.1093/mr/roab121
复制
发表时间：
2023
影响因子：
2.2
通讯作者：
Tabeta Koichi
中科院分区：
文献类型：
--
作者：
Kobayashi Tetsuo;Ito Satoshi;Murasawa Akira;Ishikawa Hajime;Tabeta Koichi
目的 评估牙周炎严重程度是否影响类风湿性关节炎 (RA) 患者对生物疾病缓解抗风湿药物 (bDMARD) 1 年的临床反应。方法在一项回顾性研究中，收集了 50 名 RA 患者的数据，这些患者在 bDMARD 治疗之前（基线）和之后接受了皮质类固醇、常规合成 DMARD 或非甾体类抗炎药物。根据牙周炎表面积 (PISA) 或疾病控制和预防中心 (CDC)/美国牙周病学会 (AAP) 病例定义，比较两个牙周炎严重程度组之间的风湿病状况结果与 22 名中度和重度牙周炎患者相比，28 名无或轻度牙周炎患者的临床疾病活动指数 (CDAI) 以及压痛和肿胀关节计数的变化显着减少（p= .02、p= .01、p= .03）。双变量和多变量分析均显示基线 CDC/AAP 定义与 CDAI 变化之间存在显着正相关 (p= .005 和 p= .0038)。然而，低 PISA 组和高 PISA 组各 25 名患者的风湿病状况相当。结论 根据 CDC/AAP 定义，基线牙周炎严重程度与 RA 患者 1 年 bDMARD 的临床反应相关。
ObjectivesTo assess whether periodontitis severity affects the clinical response to biological disease-modifying antirheumatic drugs (bDMARDs) for 1 year in rheumatoid arthritis (RA) patients.MethodsData were collected from 50 RA patients who had received corticosteroids, conventional synthetic DMARDs, or non-steroidal anti-inflammatory drugs before (baseline) and after 1 year of bDMARD therapy in a retrospective study. Rheumatologic conditions were compared between the two periodontitis severity groups according to the periodontal inflamed surface area (PISA) or Centers for Disease Control and Prevention (CDC)/American Academy of Periodontology (AAP) case definitionsResultsTwenty-eight patients with no or mild periodontitis showed significantly greater decreases in changes in Clinical Disease Activity Index (CDAI) and tender and swollen joint count in comparison to 22 patients with moderate and severe periodontitis (p= .02,p= .01, andp= .03). Both bivariate and multivariate analyses revealed a significantly positive association between the baseline CDC/AAP definitions and CDAI changes (p= .005 andp= .0038). However, rheumatologic conditions were comparable between 25 patients each in the low and high PISA groups.ConclusionsBaseline periodontitis severity according to the CDC/AAP definitions is associated with the clinical response to bDMARDs for 1 year in RA patients.