Achieving Canadian physical activity guidelines is associated with better vascular function independent of aerobic fitness and sedentary time in older adults
Achieving Canadian physical activity guidelines is associated with better vascular function independent of aerobic fitness and sedentary time in older adults
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DOI：
10.1139/apnm-2018-0033
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发表时间：
2018-10-01
影响因子：
3.4
通讯作者：
Kimmerly, Derek S.
中科院分区：
文献类型：
--
作者：
O'Brien, Myles W.;Robinson, Susan A.;Kimmerly, Derek S.
加拿大身体活动指南建议老年人每周进行150分钟的中度到剧烈的身体活动（MVPA）。活动不足的老年人可能会降低血管健康，增加心血管疾病的风险。我们在11名符合MVPA指南的老年人（7名女性;年龄，65 ± 5岁; MVPA，= 239 ± 81分钟/周）和10名不符合MVPA指南的老年人（7名女性;年龄，68 ± 9岁; MVPA，95 ± 33分钟/周）中测试了这一假设。通过超声检查评估肱动脉（BA）和腘动脉（POP）的流量介导的扩张（FMD）以及POP的硝酸甘油介导的扩张（NMD;内皮非依赖性扩张）。有氧健身（峰值摄氧量）通过间接热量测定法使用分级的最大踏车测力计测试来确定。分别使用PiezoRx和activPAL评估5天内的MVPA和久坐时间。峰值摄氧量无差异（26 +/- 10 vs. 22 +/- 10 mL O-2/（kg.min）; p = 0.26）或久坐时间（512 +/- 64 vs. 517 +/- 76 min/d; p = 0.87）;然而，那些达到MVPA指南的人的BA-FMD更高（5.1% +/- 1.3% vs. 3.6% +/- 1.7%; p = 0.03）、POP-FMD（2.6% +/- 1.1% vs. 1.3% +/- 0.8%; p = 0.006）和POP-NMD（5.1% +/- 1.7% vs. 3.3% +/- 2.1%; p = 0.04）。在合并样本中，MVPA与BA-FMD（r = 0.53; p = 0.01）和POP-NMD（r = 0.59; p = 0.005）中度相关，与POP-FMD（r = 0.85; p < 0.001）高度相关。总的来说，我们的研究结果提供了支持性证据，证明符合MVPA指南与更好的血管功能相关，并可能降低老年人患心血管疾病的风险。此外，这些数据表明，每周MVPA时间可能比有氧健身和每周久坐时间对血管功能有更大的影响。
Canadian physical activity guidelines recommend older adults accumulate 150 min of weekly moderate to vigorous physical activity (MVPA). Older adults who are insufficiently active may have reduced blood vessel health and an increased risk of cardiovascular disease. We tested this hypothesis in 11 older adults who did (7 female; age, 65 +/- 5 years; MVPA, = 239 +/- 81 min/week) and 10 older adults who did not (7 female; age, 68 +/- 9 years; MVPA, 95 +/- 33 min/week) meet MVPA guidelines. Flow-mediated dilation (FMD) in the brachial (BA) and popliteal (POP) arteries, as well as nitroglycerin-mediated dilation (NMD; endothelial-independent dilation) in the POP were assessed via ultrasonography. Aerobic fitness (peak oxygen uptake) was determined using a graded, maximal cycle ergometry test via indirect calorimetry. MVPA and sedentary time were assessed over 5 days using the PiezoRx and activPAL, respectively. There were no differences in peak oxygen uptake (26 +/- 10 vs. 22 +/- 10 mL O-2/(kg.min); p = 0.26) or sedentary time (512 +/- 64 vs. 517 +/- 76 min/day; p = 0.87) between groups; however, those who achieved the MVPA guidelines had a higher BA-FMD (5.1% +/- 1.3% vs. 3.6% +/- 1.7%; p = 0.03), POP-FMD (2.6% +/- 1.1% vs. 1.3% +/- 0.8%; p = 0.006), and POP-NMD (5.1% +/- 1.7% vs. 3.3% +/- 2.1%; p = 0.04). In the pooled sample, MVPA was moderately correlated to both BA-FMD (r = 0.53; p = 0.01) and POP-NMD (r = 0.59; p = 0.005), and strongly correlated to POP-FMD (r = 0.85; p < 0.001). Collectively, our results provide supporting evidence that meeting MVPA guidelines is associated with better vascular function and may reduce the risk of developing cardiovascular disease in older adults. Furthermore, these data suggest that weekly MVPA time may have a greater impact on blood vessel function than aerobic fitness and weekly sedentary time.