Erythroid development in the mammalian embryo
Erythroid development in the mammalian embryo
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DOI：
10.1016/j.bcmd.2013.07.006
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发表时间：
2013-12-01
影响因子：
2.3
通讯作者：
Nieves, Johnathan
中科院分区：
文献类型：
--
作者：
Baron, Margaret H.;Vacaru, Andrei;Nieves, Johnathan
红细胞生成是红细胞祖细胞产生和终末分化的过程。在所有脊椎动物中，两种形态上不同的红细胞谱系（原始的，胚胎的，和定形的，胎儿/成人）相继在卵黄囊，胎儿肝脏和骨髓中形成，并且对于正常发育是必需的。红细胞在氧运输、抗氧化和血管重塑方面已经进化出高度专门化的功能。在这里，我们回顾了哺乳动物红细胞发育的个体发育的关键特征，突出遗传和基因表达谱研究揭示的相似性和差异，并讨论了在不同发育和分化阶段识别红系细胞的方法。(C)版权所有© 2013 Elsevier Inc.
Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation. (C) 2013 Elsevier Inc All rights reserved.