The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus
The prevalence and associations of sleep disturbances in patients with systemic lupus erythematosus
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DOI：
10.1007/s10165-009-0185-x
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发表时间：
2009-08-01
影响因子：
2.2
通讯作者：
Narsimulu, Gumdal
中科院分区：
文献类型：
--
作者：
Chandrasekhara, Pradeep Kumar Shenoy;Jayachandran, Nambiar Veettil;Narsimulu, Gumdal
这项研究的目的是分析系统性红斑狼疮(SLE)患者的睡眠主诉，并确定其患病率和相关性。这项研究包括50名SLE门诊患者和同等数量的年龄和性别匹配的对照组。使用匹兹堡睡眠质量指数(PSQI)对病例和对照组的睡眠质量进行评估。使用标准化问卷对患者的抑郁情绪、功能残疾和疼痛严重程度进行评估。通过临床检查确定疾病严重程度、累积损害和纤维肌痛的存在。计算睡眠质量与疾病相关变量以及人口统计学变量之间的双变量关联。计算了一系列分层回归分析，以确定睡眠质量的独立决定因素。系统性红斑狼疮患者的PSQI评分明显高于对照组。睡眠障碍患病率为62%。功能障碍、疾病活动和抑郁情绪与睡眠障碍呈正相关。36%的患者符合ACR诊断纤维肌痛的标准。在多元回归分析中，疾病活动被发现是睡眠质量的独立决定因素。系统性红斑狼疮患者睡眠质量差的发生率比人们通常认为的要高。功能性残疾、疾病活动和抑郁情绪对系统性红斑狼疮患者的睡眠障碍有显著影响。
The aim of this study was to analyze sleep complaints in patients with systemic lupus erythematosus (SLE) and to determine its prevalence and associations. Fifty outpatients with SLE and an equal number of age- and sex-matched controls were included in the study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) in both cases and controls. Depressed mood, functional disability and pain severity were assessed in patients using standardized questionnaires. Disease severity, cumulative damage and presence of fibromyalgia were determined by clinical examination. Bivariate associations between sleep quality and disease-related variables as well as demographic variables were calculated. A series of hierarchical regression analyses were computed to determine the independent determinant of sleep quality. PSQI scores were significantly higher in patients with SLE. Prevalence of sleep disturbance was 62%. Functional disability, disease activity and depressed mood correlated positively with sleep disturbances. 36% of the patients satisfied ACR criteria for fibromyalgia. In multiple regression analyses disease activity was found to be an independent determinant of sleep quality. The prevalence of poor sleep quality in patients with SLE was higher than it is generally perceived to be. Functional disability, disease activity and depressed mood contributed significantly to sleep disturbances in SLE.