Glutathione peroxidase 1 C593T polymorphism is associated with lobar intracerebral hemorrhage
Glutathione peroxidase 1 C593T polymorphism is associated with lobar intracerebral hemorrhage
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DOI：
10.1159/000126918
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发表时间：
2008-01-01
影响因子：
2.9
通讯作者：
Szczudlik, Andrzej
中科院分区：
文献类型：
--
作者：
Pera, Joanna;Slowik, Agnieszka;Szczudlik, Andrzej
背景资料：氧化应激在血管病理学中起重要作用，并参与了原发性脑出血（PICH）的病理生理过程。谷胱甘肽过氧化物酶1（GPX 1）是抗氧化系统的关键酶。在这里，我们调查是否GPX 1基因的功能性C593 T多态性与波兰人口中的PICH。方法：对192例PICH患者和197例年龄和性别相匹配的无关对照者进行基因分型。所有人都是高加索人。采用聚合酶链反应/限制性片段长度多态性（PCR-RFLP/RFLP）方法分析GPX 1基因C593 T多态性。结果如下：多变量Logistic回归分析显示，T等位基因基因与整个PICH组（OR = 1.53; 95%CI = 1.02-2.29）和肺叶PICH（OR = 2.36; 95%CI = 1.31-4.26）之间存在显著相关性，但与非肺叶PICH（OR = 1.19; 95%CI = 0.75-1.89）之间无显著相关性。结论：在波兰人群中，我们发现GPX 1多态性与脑叶PICH呈正相关。版权所有（C）2008 S. Karger AG，巴塞尔。
Background: Oxidative stress plays an important role in vascular pathology and contributes to the pathophysiology of primary intracerebral hemorrhage (PICH). Glutathione peroxidase 1 (GPX1) is a key enzyme of the antioxidant system. Here, we investigated whether a functional C593T polymorphism of GPX1 gene is associated with PICH in a Polish population. Methods: Genotyping was performed in 192 PICH patients and 197 unrelated controls matched for age and sex. All were of Caucasian origin. The C593T GPX1 polymorphism was investigated using the polymerase chain reaction/restriction fragment length polymorphism method. Results: Multivariable logistic regression analysis revealed a significant association between genotypes containing the T allele and the entire PICH group (OR = 1.53; 95% CI = 1.02-2.29) and lobar PICH (OR = 2.36; 95% CI = 1.31-4.26) but not nonlobar PICH (OR = 1.19; 95% CI = 0.75-1.89). Conclusions: We found a positive association between the studied GPX1 polymorphism and lobar PICH in a Polish population. Copyright (C) 2008 S. Karger AG, Basel.