AMPHOTERIC POLYELECTROLYTES .2. COPOLYMERS OF METHACRYLIC ACID AND DIETHYLAMINOETHYL METHACRYLATE
AMPHOTERIC POLYELECTROLYTES .2. COPOLYMERS OF METHACRYLIC ACID AND DIETHYLAMINOETHYL METHACRYLATE
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DOI：
10.1021/ja01122a047
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发表时间：
1952-01-01
影响因子：
15
通讯作者：
PINNER, H
中科院分区：
文献类型：
--
作者：
ALFREY, T;FUOSS, RM;PINNER, H
甲基丙烯酸和，-二乙基氨基乙基甲基丙烯酸酯的共聚物存在的聚阳离子在低pH值，作为聚阴离子在高pH值，并可能作为聚两性离子在中间pH值。每种共聚物都具有一定的等电点，其特征在于溶液粘度最小，电泳迁移率反转。随着共聚物中胺/酸比例的增加，等电点向更高的pH值移动。如果胺或酸的成分大量过量存在，等电点会扩大到聚合物不溶的pH范围内。含有酸和碱性基团的合成乙烯基共聚物可以提供蛋白质溶液行为某些方面的有用类似物。3以前的出版物4· 5已经讨论了甲基丙烯酸与乙烯基吡啶的共聚物。上述共聚物可溶于酸和碱，但在中性pH范围内表现出水不溶性。这归因于吡啶基团的弱碱性，这将阻止两性离子的形成。本文介绍了由甲基丙烯酸二乙氨基乙酯（DEAM）单体提供的含强碱性基团的共聚物。
Copolymers of methacrylic acid and,-diethylaminoethyl methacrylate exist as polycations at low pH, as polyanions at high pH, and probably as polyzwitterions at intermediate pH values. Each copolymer possesses a definite isoelectric point, characterized by a minimum in the solution viscosity and by a reversal in the electrophoretic mobility. Theisoelectric point moves to higher pH values, as the amine/acid ratio in the copolymer is increased. If either the amine or the acid con-stituent is present in large excess, the isoelectric point broadens into a pH range in which the polymer is insoluble.Synthetic vinyl copolymers containing both acid and basic groups may provide useful analogs to certain aspects of the solution behavior of proteins. 3 Previous publications4· 5 have discussed copolymers of methacrylic acid with vinylpyridine. The above copolymers were soluble in acid and in al-kali, but exhibited water-insolubility in the neutral pH range. This was ascribed to the weakly basic character of the pyridine groups, which would preclude zwitterion formation. This paper describes copolymerscontaining stronger basic groups, contributed by the monomer,-diethylaminoethyl methacrylate (DEAM).