PHOTODYNAMIC INACTIVATION OF YEAST CELLS SENSITIZED BY HEMATOPORPHYRIN
PHOTODYNAMIC INACTIVATION OF YEAST CELLS SENSITIZED BY HEMATOPORPHYRIN
复制标题
血卟啉致敏的酵母细胞的光动力失活
DOI：
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发表时间：
1980
影响因子：
3.3
通讯作者：
T. Eklund
中科院分区：
文献类型：
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作者：
A. G. Kvello Stenstrøm;J. Moan;G. Brunborg;T. Eklund
摘要：酵母细胞通过血卟啉和光处理而失活。失活主要由单线态氧介导。单线态氧的量子产率随着pH值的增加而增加，而细胞失活的效率随着pH值的增加而降低。处于稳定期的细胞比处于指数生长期的细胞对治疗的抵抗力要强得多。膜损伤似乎是光失活的主要决定步骤。
Abstract— Yeast cells are inactivated by treatment with hematoporphyrin and light. The inactivation is mainly mediated by singlet oxygen. The quantum yield of singlet oxygen increases with increasing pH, while the efficiency of cellular inactivation decreases with increasing pH. Cells in the stationary phase are much more resistant to the treatment than cells in exponential growth. Membrane damage seems to be the main determining step in the photoinactivation.