Path to Illness Intrusiveness: What Symptoms Affect the Life of People Living With Multiple Sclerosis?
Path to Illness Intrusiveness: What Symptoms Affect the Life of People Living With Multiple Sclerosis?
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DOI：
10.1016/j.apmr.2017.03.012
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发表时间：
2017-07-01
影响因子：
4.3
通讯作者：
Mayo, Nancy E.
中科院分区：
文献类型：
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作者：
Bouchard, Vanessa;Duquette, Pierre;Mayo, Nancy E.
目的：确定身体、情感和认知障碍对多发性硬化症（MS）患者疾病侵入性的直接和间接影响。设计：对2008年收集的横断面数据集进行二次分析，以确定MS患者的性别差异。设置：三个MS诊所。参与者：在2008年招募并评估了1995年后诊断为MS的女性和男性的随机样本（N=189）。干预措施：不适用。主要结果测量：疾病侵入性评定量表（使用Rasch分析的更新版本）。结果：路径分析产生了一个显着的模型（非标准拟合指数，0.9913;标准拟合指数，0.9846），数据与模型拟合充分（拟合优度指数，0.9781;：x（2）=21.41; P= 0.2084）。该模型解释了疾病侵入性的55%的方差。模型中仅代表了情感和身体方面，因为变量减少后没有认知障碍。该模型显示了完整的调解效果疲劳的身体功能variables.Conclusions：该项目带来了新的证据对疾病侵入性的概念化作为一个结构，允许未来的干预措施，希望针对疾病侵入性或疾病的影响进行设计。它还提供了统计证据，表明不仅将疲劳作为一种症状，而且还将其作为其他损伤的后果进行治疗的重要性。(C)2016年美国康复医学大会
Objective: To determine the direct and indirect effects of physical, emotional, and cognitive impairments on illness intrusiveness in people with multiple sclerosis (MS).Design: Secondary analysis of a cross-sectional data set collected in 2008 to identify sex differences in people living with MS.Setting: Three MS clinics.Participants: A random sample (N=189) of women and men diagnosed with MS after 1995 were recruited and evaluated in 2008.Interventions: Not applicable.Main Outcome Measure: Illness Intrusiveness Rating Scale (updated version using Rasch analysis).Results: Path analysis yielded a model that was significant (nonnormed fit index,.9913; normed fit index,.9846) with adequate fit of the data-to the model (goodness of fit index,.9781; :x(2)=21.41; P=.2084). The model explained 55% of the variance of illness intrusiveness. Only emotional and physical aspects were represented in the model because no cognitive impairment stayed after variable reduction. The model showed the complete mediation effect of fatigue on the physical function variables.Conclusions: This project brings new evidence toward the conceptualization of illness intrusiveness as a construct allowing future interventions that wish to target illness intrusiveness or disease impact to be designed. It also presented statistical evidence of the importance of treating fatigue not only as a symptom but also as a consequence of other impairments. (C) 2016 by the American Congress of Rehabilitation Medicine