Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury.
Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury.
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DOI：
10.1161/strokeaha.110.595058
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发表时间：
2010-10
期刊：
影响因子：
8.3
通讯作者：
Powers WJ
中科院分区：
文献类型：
--
作者：
Powers WJ
Non-traumatic intracerebral hemorrhage (ICH) remains a devastating condition with 30-day mortality rates of 35–52%. Until the pathophysiology of this condition is better understood, it will not be possible to develop effective therapies. Studies of cerebral blood flow and metabolism in patients with acute ICH show similar abnormalities to those that occur in patients with traumatic brain injury (TBI), thus raising the question whether there are common mechanisms of injury shared by the two conditions. In both ICH and TBI, there is an early reduction in the cerebral metabolic rate of oxygen without ischemia, mitochondrial dysfunction and transient focal increases in regional glucose metabolism that occur after a few days. ICH and TBI share barotrauma from pressure waves that propagate through the intracranial contents as a common mechanism of brain injury. Recent data demonstrating contralateral hemispheric damage in patients with acute ICH provides further support for this theory of common injury mechanisms.
