Sex differences in resting EEG power in Fragile X Syndrome.
Sex differences in resting EEG power in Fragile X Syndrome.
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DOI：
10.1016/j.jpsychires.2021.03.057
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发表时间：
2021-06
影响因子：
4.8
通讯作者：
Erickson CA
中科院分区：
文献类型：
--
作者：
Smith EG;Pedapati EV;Liu R;Schmitt LM;Dominick KC;Shaffer RC;Sweeney JA;Erickson CA
电生理改变可能代表脆性X综合征（FXS）中受损的神经认知过程和其他表型特征的神经基质。然而，生物性别在区分FXS与典型发育的脑电图（EEG）模式中的作用尚未确定。这限制了EEG在寻找FXS损伤生物标志物方面的使用，以及这些标志物的应用，以增强我们对潜在神经机制的理解，从而加快治疗发现。本研究采用聚类分析方法，对FXS男性和女性以及年龄和性别匹配的典型发育对照组（TDC）的静息状态下的地形相对脑电图功率进行了研究。虽然在FXS中，θ和低β功率的变化在男性和女性之间相似，但在α、上β、γ和ε频段的相对功率因性别而异。后续分析表明，个体α峰值频率（IAPF）是一个连续的变量，可以捕捉神经发育障碍中θ和α范围的非典型性，也因性别而异。最后，男性在听觉过滤任务中的表现与theta功率相关，而女性在FXS任务中的表现与theta功率无关。我们讨论了生理性别对FXS静息状态脑电图功率差异的影响，因为它与FXS神经认知缺陷的潜在gaba能和谷氨酸能病因有关。
Electrophysiological alterations may represent a neural substrate of impaired neurocognitive processes and other phenotypic features in Fragile X Syndrome (FXS). However, the role of biological sex in electroencephalography (EEG) patterns that differentiate FXS from typical development has not been determined. This limits use of EEG in both the search for biomarkers of impairment in FXS as well as application of those markers to enhance our understanding of underlying neural mechanisms to speed treatment discovery. We investigated topographical relative EEG power in participants at rest in a sample of males and females with FXS and in age- and sex-matched typically developing controls (TDC) using a cluster-based analysis. While alterations in theta and low beta power were similar across males and females in FXS, relative power varied by sex in the alpha, upper beta, gamma, and epsilon frequency bands. Follow up analyses showed that Individual Alpha Peak Frequency (IAPF), a continuous variable that may capture atypicalities across the theta and alpha ranges in neurodevelopmental disorders, also varied by sex. Finally, performance on an auditory filtering task correlated with theta power in males, but not females with FXS. The impact of biological sex on resting state EEG power differences in FXS is discussed as it relates to potential GABAergic and glutamatergic etiologies of neurocognitive deficits in FXS.
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影响因子：
6.1
作者：
Jonak, Carrie R.;Lovelace, Jonathan W.;Ethell, Iryna M.;Razak, Khaleel A.;Binder, Devin K.
通讯作者：
Binder, Devin K.
DOI：
10.1016/0013-4694(80)90403-4
发表时间：
1980-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
MATTHIS, P;SCHEFFNER, D;STOLZIS, L
通讯作者：
STOLZIS, L
影响因子：
4.7
作者：
Clarke, AR;Barry, RJ;Selikowitz, M
通讯作者：
Selikowitz, M
影响因子：
3.7
作者：
Cragg, Lucy;Kovacevic, Natasa;Paus, Tomas
通讯作者：
Paus, Tomas
影响因子：
4.7
作者：
Hagemann, Dirk;Hewig, Johannes;Naumann, Ewald
通讯作者：
Naumann, Ewald