Objective sleep interruption and reproductive hormone dynamics in the menstrual cycle.
Objective sleep interruption and reproductive hormone dynamics in the menstrual cycle.
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月经周期中的客观睡眠中断和生殖激素动态。
DOI：
10.1016/j.sleep.2014.02.003
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发表时间：
2014
期刊：
影响因子：
4.8
通讯作者：
Joffe,Hadine
中科院分区：
文献类型：
--
作者：
Sharkey,KatherineM;Crawford,SybilL;Kim,Semmie;Joffe,Hadine
目的女性在月经周期的经前期和月经期有更大的睡眠障碍。然而，月经周期相关的睡眠障碍的假定激素基础还没有直接调查。我们研究了协会的客观措施，睡眠片段与生殖激素水平在健康，绝经前women.MethodsTwenty-seven每月月经的妇女在两个时间点测量激素水平在一个单一的月经周期：卵泡期和排卵期中期黄体期。在排卵期/黄体中期抽血当天记录一个晚上的家庭多导睡眠图（PSG）。血清孕酮、雌二醇和雌酮水平与多导睡眠图和孕酮变化率同步从卵泡抽血到PSG的PROGslope与对数转换的入睡后觉醒（lnWASO%）和觉醒次数/睡眠小时相关（lnWake-Index）使用线性回归。（InWAS0% p= 0.016; InWake-Indexp = 0.08）和更高的同时雌酮水平（InWAS0% p= 0.03; InWake-Indexp = 0.01），但在考虑PROGslope后，雌酮对WAS 0的影响消失。WASO%和唤醒指数与伴随的孕酮或雌二醇levels.ConclusionsA陡峭的速度上升孕酮水平从卵泡期通过中期黄体期与显着更大的WASO，建立生殖激素动态和睡眠片段在月经周期的黄体期之间的联系。
ObjectivesWomen report greater sleep disturbance during the premenstrual phase of the menstrual cycle and during menses. However, the putative hormonal basis of perceived menstrual cycle-related sleep disturbance has not been investigated directly. We examined associations of objective measures of sleep fragmentation with reproductive hormone levels in healthy, premenopausal women.MethodsTwenty-seven women with monthly menses had hormone levels measured at two time points during a single menstrual cycle: the follicular phase and the peri-ovulatory to mid-luteal phase. A single night of home polysomnography (PSG) was recorded on the day of the peri-ovulatory/mid-luteal-phase blood draw. Serum progesterone, estradiol, and estrone levels concurrent with PSG and rate of change in progesterone (PROGslope) from the follicular blood draw to PSG were correlated with log-transformed wake after sleep onset (lnWASO%) and number of wakes/hour of sleep (lnWake-Index) using linear regression.ResultsSleep was more fragmented in association with a steeper PROGslope (lnWASO%p= 0.016; lnWake-Indexp= 0.08) and higher concurrent estrone level (lnWASO%p= 0.03; lnWake-Indexp= 0.01), but the effect of estrone on WASO was lost after accounting for PROGslope. WASO% and Wake-Index were not associated with concomitant progesterone or estradiol levels.ConclusionsA steeper rate of rise in progesterone levels from the follicular phase through the mid-luteal phase was associated with significantly greater WASO, establishing a link between reproductive hormone dynamics and sleep fragmentation in the luteal phase of the menstrual cycle.