25 Years of Tension over Actin Binding to the Cadherin Cell Adhesion Complex: The Devil is in the Details.
25 Years of Tension over Actin Binding to the Cadherin Cell Adhesion Complex: The Devil is in the Details.
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DOI：
10.1016/j.tcb.2016.04.010
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发表时间：
2016-07
影响因子：
19
通讯作者：
W. Nelson;W. Weis
中科院分区：
文献类型：
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作者：
W. Nelson;W. Weis
在过去的 25 年里，对于钙粘蛋白细胞粘附复合物（包含 F-肌动蛋白结合蛋白）如何与肌动蛋白细胞骨架结合的理解发生了概念（重新）演变。现在结构、生化和细胞生物学结果之间存在良好的协同作用，即钙粘蛋白-连环蛋白复合物在力作用下与F-肌动蛋白结合。
Over the past 25 years, there has been a conceptual (re)evolution in understanding how the cadherin cell adhesion complex, which contains F-actin-binding proteins, binds to the actin cytoskeleton. There is now good synergy between structural, biochemical, and cell biological results that the cadherin-catenin complex binds to F-actin under force.