Universal One-Pot and Scalable Synthesis of SERS Encoded Nanoparticles
Universal One-Pot and Scalable Synthesis of SERS Encoded Nanoparticles
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DOI：
10.1021/cm504251h
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发表时间：
2015-02-10
影响因子：
8.6
通讯作者：
Alvarez-Puebla, Ramon A.
中科院分区：
文献类型：
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作者：
Mir-Simon, Bernat;Reche-Perez, Irene;Alvarez-Puebla, Ramon A.
编码颗粒是用于多重高通量筛选的最有力的方法之一。基于表面增强拉曼散射（Sers）的编码原则上可以避免由于常规替代方案而导致的许多固有限制，因为它减少了阅读时间和粒度，同时允许几乎无限的编码。不幸的是，用于合成制备这些颗粒的方法是繁琐的;经常受到有限的再现性（与标准方案中采用的聚合物的尺寸分布的大波动相关）;并且迄今为止，仅限于少量的分子。在这里，我们报告了一个通用的，一锅法，廉价的，可扩展的合成方案，用于制造SERS编码的纳米粒子。这种合成策略是高度可重复的，与所使用的拉曼编码的化学性质和大小无关（测试了31种不同的编码），并且在升范围内可扩展，而不影响编码结构的最终性质。此外，所制备的编码纳米颗粒的SERS效率优于传统方法生产的材料的SERS效率，同时显示出批次之间显着的可重复性，并且具有上级。这种编码策略可以很容易地应用于不同材料和形状的纳米颗粒。
Encoded particles are one of the most powerful approaches for multiplex high-throughput screening. Surface-enhanced Raman scattering (SERS) based codification can, in principle, avoid many of the intrinsic limitations due to conventional alternatives, as it decreases the reading time and particle size while allowing for almost unlimited codification. Unfortunately, methods for the synthetic preparation of these particles are tedious; often subjected to limited reproducibility (associated with large fluctuations in the size distributions of the polymers employed in the standard protocols); and to date, limited to a small amount of molecules. Herein, we report a universal, one-pot, inexpensive, and scalable synthetic protocol for the fabrication of SERS-encoded nanoparticles. This synthetic strategy is highly reproducible, independent of the chemical nature and size of the Raman code used (31 different codes were tested) and scalable in the liter range without affecting the final properties of the encoded structures. Furthermore, the SERS efficiency of the fabricated encoded nanoparticles is superior to that of the materials produced by conventional methods, while showing a remarkable reproducibility from batch to batch. This encoding strategy can easily be applied to nanoparticles of different materials and shapes.