beta-Endorphin: isolation, amino acid sequence and synthesis of the hormone from horse pituitary glands.
beta-Endorphin: isolation, amino acid sequence and synthesis of the hormone from horse pituitary glands.
复制标题
β-内啡肽：马垂体激素的分离、氨基酸序列和合成。
DOI：
10.1111/j.1399-3011.1981.tb02978.x
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Tseng,LF
中科院分区：
文献类型：
--
作者：
Li,CH;Ng,TB;Yamashiro,D;Chung,D;HammondsJr,RG;Tseng,LF
β-内啡肽已经从马的垂体中分离出来。其氨基酸序列与绵羊、牛和骆驼β-内啡肽的氨基酸序列相同，除了第6位的苏氨酸残基被丝氨酸取代。马β-内啡肽也通过固相法合成。与人类激素相比，马β-内啡肽在大鼠膜制备物中的受体结合活性是其3倍，在小鼠甩尾试验中的镇痛效力是其1.6倍。
Beta‐endorphin has been isolated from equine pituitaries. Its amino acid sequence is identical to that of ovine, bovine and camel β‐endorphins except for substitution of the threonine residue at position 6 by serine. The equine β‐endorphin has also been synthesized by the solid‐phase method. In comparison with the human hormone, equine β‐endorphin was shown to possess 3 times the receptor‐binding activity in rat membrane preparations and 1.6 times the analgesic potency in the mouse tail‐flick assay.