Effects of dietary retinyl palmitate and selenium on tumoricidal capacity of macrophages in mice undergoing tumor promotion.
Effects of dietary retinyl palmitate and selenium on tumoricidal capacity of macrophages in mice undergoing tumor promotion.
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膳食视黄基棕榈酸酯和硒对肿瘤促进小鼠巨噬细胞杀肿瘤能力的影响。
DOI：
10.1016/0304-3835(87)90089-9
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发表时间：
1987
期刊：
影响因子：
9.7
通讯作者：
Gensler,HL
中科院分区：
文献类型：
--
作者：
Watson,RR;Moriguchi,S;Gensler,HL
在 CD-1 小鼠中给予膳食视黄酯棕榈酸酯 22-30 周，首先使用 0.15 μmol 7,12-二甲基苯并[a]-蒽 (DMBA)，然后每周两次使用 8 nmol 12-O-十四烷酰佛波醇-13-乙酸酯 (TPA) 进行促进。这种治疗导致了选定数量的分离腹膜巨噬细胞（PM）的杀肿瘤能力和皮肤肿瘤预防的剂量反应。在 350 I.U./g 饮食中，棕榈酸视黄酯 (RP) 也会导致 DM 数量增加 3 倍。 RP 通过增加巨噬细胞的数量和个体细胞毒性能力，显着提高巨噬细胞宿主防御的总能力。饮用水中浓度为 2 ppm 的硒 (Se) 并没有增强 PM 的杀肿瘤能力，尽管它确实使小鼠肿瘤负荷减少了 60%。
Dietary retinyl palmitate was administered for 22–30 weeks in CD-1 mice which had been initiated with 0.15 μmol of 7,12-dimethylbenz[a]-anthracene (DMBA) and promoted with 8 nmol of 12-O-tetradecanoylphorbol-13-acetate (TPA) twice weekly thereafter. This treatment resulted in a dose response in both the tumoricidal capacity of a selected number of isolated peritoneal macrophages (PM) and in skin tumor prevention. At 350 I.U./g of diet, retinyl palmitate (RP) also resulted in a 3-fold increase in the number of DM. RP significantly increased the total capacity of macrophage host defenses by increasing the number and individual capacity for cytotoxicity. Selenium (Se), at 2 parts/million in the drinking water, did not enhance PM tumoricidal capacity, although it did result in 60% reduction of mouse tumor burden.