Mutagenesis and more: umuDC and the Escherichia coli SOS response.
Mutagenesis and more: umuDC and the Escherichia coli SOS response.
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诱变及更多：umuDC 和大肠杆菌 SOS 反应。
DOI：
10.1093/genetics/148.4.1599
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发表时间：
1998
期刊：
影响因子：
3.3
通讯作者：
Walker,GC
中科院分区：
文献类型：
--
作者：
Smith,BT;Walker,GC
细胞对DNA损伤的反应被最广泛地研究是大肠杆菌的SOS反应。对SOS反应的分析使人们对DNA损伤后提高细胞存活率的转录和翻译后调控过程以及对DNA损伤诱导的突变(即SOS突变)有了新的见解。SOS突变需要recA和umuDC基因产物，其机制基础是DNA聚合酶III的改变，使其能够复制含有错误编码和非编码损伤的DNA。讨论了目前正在进行的SOS突变机制的研究，以及最近的观察结果表明，umuDC操纵子可能在DNA损伤发生后对大肠杆菌细胞周期的调节中发挥作用。
The cellular response to DNA damage that has been most extensively studied is the SOS response of Escherichia coli. Analyses of the SOS response have led to new insights into the transcriptional and posttranslational regulation of processes that increase cell survival after DNA damage as well as insights into DNA-damage-induced mutagenesis, i.e., SOS mutagenesis. SOS mutagenesis requires the recA and umuDC gene products and has as its mechanistic basis the alteration of DNA polymerase III such that it becomes capable of replicating DNA containing miscoding and noncoding lesions. Ongoing investigations of the mechanisms underlying SOS mutagenesis, as well as recent observations suggesting that the umuDC operon may have a role in the regulation of the E. coli cell cycle after DNA damage has occurred, are discussed.