Bone microstructure in healthy men measured by HR-pQCT: Age-related changes and their relationships with DXA parameters and biochemical markers
Bone microstructure in healthy men measured by HR-pQCT: Age-related changes and their relationships with DXA parameters and biochemical markers
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DOI：
10.1016/j.bone.2021.116252
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发表时间：
2021-11-15
期刊：
影响因子：
4.1
通讯作者：
Osaki, Makoto
中科院分区：
文献类型：
--
作者：
Doi, Mitsuru;Chiba, Ko;Osaki, Makoto
目的：本横断面研究的主要目的是研究男性高分辨率外周定量计算机断层扫描（HR-pQCT）骨微结构、双能X线吸收测定法（DXA）骨密度（aBMD）和骨相关生化标志物的年龄相关变化特征。本研究的第二个目的是研究骨微结构与aBMD和生化标记物的关系。方法：研究对象为128名日本健康男性（20-97岁）。使用第二代HR-pQCT测量桡骨远端和胫骨的骨显微结构;使用DXA测量股骨近端和腰椎的aBMD;使用抗酒石酸酸性磷酸酶-5b通过血液测试测量TRACP-5 b、I型前胶原-N-前肽（P1 NP）、25（OH）维生素D和戊糖苷的浓度。在骨小梁中，骨小梁体积BMD（Tb.vBMD）和骨小梁数量（Tb.N）随年龄增长而降低（r =-0.23，-0.35）（r =-0.36，-0.33），小梁分离桡骨和胫骨的Tb.Sp值和星星容积（V*ms）均随年龄增长而增大（r = 0.29，0.41）（r = 0.34，0.38）。在桡骨和胫骨中，皮质体积BMD（Ct.vBMD）随年龄增长而降低（r =-0.25，-0.52），皮质孔隙率（Ct.Po）随年龄增长而升高（r = 0.67，0.62）。胫骨的皮质厚度（Ct.Th）和皮质区（Ct.Ar）随年龄增长而降低（r = -0.40）（r = -0.43），而在桡骨，它们保持不变，骨膜周长（Ct.Pm）随年龄增长而升高（r = 0.35）.股骨近端和P1 NP的aBMD随着年龄的增加而降低，而戊糖苷酶则随着年龄的增加而升高，而腰椎的aBMD、TRACP-5 b、DXA、HR-pQCT与股骨aBMD、胫骨Tb.vBMD、Ct.Ar相关性较强（r = 0.61）（r = 0.61），而与Ct. Po无相关性。在生化指标与HR-pQCT的相关性中，TRACP-5 b和总P1 NP与Ct、vBMD呈负相关（r = -0.31）（r = -0.35），但几乎没有看到其他相关性。男性中骨微结构的骨密度相关变化的特征是与骨小梁数量减少、骨小梁结构空化相关的骨小梁和皮质vBMD减少，和增加的皮质孔隙度。股骨aBMD与胫骨骨微结构密切相关，而腰椎aBMD和股骨aBMD与Ct.Po无关，生化指标与骨微结构几乎没有关系。
Objective: The primary purpose of this cross-sectional study was to investigate the characteristics of age-related changes in bone microstructure on high-resolution peripheral quantitative computed tomography (HR-pQCT), areal bone mineral density (aBMD) on dual-energy X-ray absorptiometry (DXA), and bone-related biochemical markers in men. The secondary purpose of this study was to examine how bone microstructure is related to aBMD and biochemical markers.Methods: The subjects were 128 healthy Japanese men (20-97 years old). Bone microstructure was measured in the distal radius and tibia using second-generation HR-pQCT; aBMD in the proximal femur and lumbar spine was measured with DXA; and tartrate-resistant acid phosphatase-5b (TRACP-5b), type I procollagen-N-propeptide (P1NP), 25(OH) vitamin D, and pentosidine concentrations were measured by blood tests.Results: In trabecular bone, the trabecular volumetric BMD (Tb.vBMD) and trabecular number (Tb.N) were lower with age (r = -0.23, -0.35) (r = -0.36,-0.33), and trabecular separation (Tb.Sp) and the star volume of marrow space (V*ms) were higher with age (r = 0.29, 0.41) (r = 0.34, 0.38) in both the radius and tibia. In cortical bone, cortical volumetric BMD (Ct.vBMD) was lower with age (r = -0.25, -0.52), and cortical porosity (Ct.Po) was higher with age (r = 0.67, 0.62) in both the radius and tibia. In the tibia, cortical thickness (Ct.Th) and cortical area (Ct.Ar) were lower with age (r = -0.40) (r = -0.43), whereas, in the radius, they were maintained, and periosteal perimeter (Ct.Pm) was higher with age (r = 0.35).aBMD in the proximal femur and P1NP were lower, and pentosidine was higher with increased age, whereas aBMD in the lumbar spine, TRACP-5b, and 25(OH) vitamin D had no relationships with age.DXA and HR-pQCT showed strong correlations particularly with femoral aBMD and tibial Tb.vBMD and Ct.Ar (r = 0.61) (r = 0.61), whereas no DXA parameters were related with Ct.Po. In correlations between biochemical markers and HR-pQCT, TRACP-5b and total P1NP were negatively correlated with Ct.vBMD (r = -0.31) (r = -0.35), but almost no other correlations were seen.Conclusions: Age-related changes of the bone microstructure in men were characterized by decreases in trabecular and cortical vBMD associated with decreased trabecular number, cavitation of the trabecular structure, and increased cortical porosity. Femoral aBMD was strongly related to bone microstructure in the tibia, whereas both lumbar aBMD and femoral aBMD were not related to Ct.Po, and biochemical markers showed almost no relationships with bone microstructure.