Progress of photodynamic therapy in gastric cancer.
Progress of photodynamic therapy in gastric cancer.
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DOI：
10.1155/dte.5.175
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Okuda S
中科院分区：
文献类型：
--
作者：
Mimura S;Narahara H;Otani T;Okuda S
本文就光动力治疗胃癌的研究进展及临床效果作一综述。(1)我们将整个病灶和5mm的边缘纳入放射场。事先进行了印墨注射标记，显示辐照场。(2)建立了氩染料激光器的标准光剂量为90 J/cm2，脉冲波激光器的标准光剂量为60 J/cm2。(3)采用一种新型准分子染料激光模型，以80hz脉冲频率发射4mJ/脉冲，将PDT可治愈癌变灶的大小从直径3cm即7 cm2扩大到直径4cm即13 cm2。(4) PDT可治疗的肿瘤浸润深度从约4mm，即粘膜下层（SM-1）的浅表部分增加到10mm以上，即适当的肌肉层。这些改进在很大程度上归功于脉冲激光器，它所引起的光动力作用比连续波激光器允许更深的穿透。(5)采用侧视纤维镜对胃PDT病变进行90°角度照射。(6)我们设计了一种简单切割的石英光导纤维，其末端有一个加厚的螺旋弹簧。(7)研制了一种用于PDT的内窥镜光照射装置，实现了准确、高效的光照射。由于这些改进，即使在较低的光剂量照射下也能获得较高的治愈率。
Progress of photodynamic therapy (PDT) in gastric cancer and the clinical outcome are described in this paper. (1) We included the whole lesion and a 5 mm margin in the field for irradiation. Marking by injection of India-ink showing the irradiation field was performed beforehand. (2) We established the standard light dose to be 90 J/cm2 for an argon dye laser and 60 J/cm2 for a pulse wave laser. (3) The size of cancerous lesion curable by PDT was expanded from 3 cm in diameter, i.e. 7 cm2 in area to 4 cm in diameter, i.e. 13 cm2 by employing a new excimer dye laser model, which could emit 4mJ/pulse with 80 Hz pulse frequency. (4) The depth of cancer invasion which could be treated by PDT was increased from about 4 mm, i.e. the superficial part of the submucosal layer (SM-1) to more than 10 mm in depth, i.e. the proper muscular layer. These improvements owe much to the pulse laser, the photodynamic action induced by which permits deeper penetration than that of a continuous wave laser. (5) We employed a side-viewing fiberscope for gastric PDT to irradiate the lesion from an angle of 90°. (6) We designed a simple cut quartz fiber for photoradiation with a spiral spring thickened toward the end. (7) We developed an endoscopic device for photoradiation in PDT which achieves accurate and efficient irradiation. As a result of these improvements a higher cure rate was obtained even with a lower light dose of irradiation.