Ultrasonographic compared to histologic sizing of benign and malignant breast lesions
Ultrasonographic compared to histologic sizing of benign and malignant breast lesions
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DOI：
10.1055/s-2006-924035
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发表时间：
2006-04-01
影响因子：
2.7
通讯作者：
Grunwald, S.
中科院分区：
文献类型：
--
作者：
Ohlinger, R.;Frese, H.;Grunwald, S.
目的：探讨乳腺良恶性病变超声检查与组织学分级的相关性。超声检查是一个重要的辅助手段，因为触诊结果不足以决定手术治疗，例如保留组织的切除术和乳房切除术。体检也不足以确定是进行手术还是进行初级化疗。方法：在两年的时间里，前瞻性地收集乳房超声和相应的组织学尺寸数据。每个病变获得的最大测量值被输入到分析中。结果：281个病灶中，良性152个(54.1%)，恶性129个(45.9%)。经超声检查，10 mm以下肿瘤中74.6%为良性肿瘤。199例均有超声和组织学大小资料。7名患者接受了新辅助化疗，剩下192个病灶等待最终分析。超声检查，肿块大小在3至86 mm之间(平均18.1 mm)。良性病变平均大小为15.3 mm，恶性病变平均大小为21.4 mm。所有大于50 mm的病变均为恶性。超声检查有轻微高估恶性病变大小和低估良性病变大小的趋势。在所有192例中，33.9%(n=65)的超声和组织学测量结果在2 mm以内。结论：由于精确的病变大小，乳腺超声作为一种术前分期工具具有很大的潜力。
Aim: This study aims to evaluate the correlation between ultrasonographic and histologic sizing of benign and malignant breast lesions. Ultrasonography is an important adjunct, because palpatory findings are insufficient to decide about the surgical management, e.g. tissue-sparing resection versus mastectomy. Neither does the physical examination suffice to determine if to proceed with surgery or primary chemotherapy. Method: Over a two-year period, breast ultrasonographic and the corresponding histologic sizing data were prospectively collected. The largest measurement obtained for each lesion was entered into the analysis. Results: Among a total number of 281 lesions, 152 (54.1%) were benign and 129 (45.9%) malignant. Measured by ultrasonography, 74.6% of tumors up to 10 mm are benign. Both ultrasonographic and histologic size data were available in 199 cases. Seven patients had received neoadjuvant chemotherapy, leaving 192 lesions for final analysis. By ultrasonography, lesions measured between 3 and 86 mm (mean 18.1 mm) in size. The average size of benign lesions was 15.3 mm, the average size of malignant lesions 21.4 mm. All lesions larger than 50 mm were malignant. There is a trend toward slight overestimation of the size of malignant and underestimation of the size of benign lesions by ultrasonography. In 33.9% (n = 65) of all 192 cases, ultrasonographic and histologic measurements agreed to within 2 mm. Conclusion: Due to precise lesion sizing, breast ultrasonography possesses a significant potential as a preoperative staging tool.