Feedback of the amygdala globally modulates visual response of primary visual cortex in the cat
Feedback of the amygdala globally modulates visual response of primary visual cortex in the cat
复制标题
杏仁核的反馈全局调节猫初级视觉皮层的视觉反应
DOI：
10.1016/j.neuroimage.2013.09.010
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发表时间：
2014-01-01
期刊：
影响因子：
5.7
通讯作者：
Yu, Hongbo
中科院分区：
文献类型：
--
作者：
Chen, Yuanxin;Li, Hongjian;Yu, Hongbo
杏仁核是情绪行为的一个重要中心，它影响着其他皮质区域。最近在猫和猴这两种视觉研究的动物模型中报道了从杏仁核到初级视觉皮层的长反馈投射。然而，这些广泛预测的详细功能作用在很大程度上仍然未知。本研究采用内源性信号光学成像技术，研究了猫杏仁核基底核注射局灶性药物后初级视皮层的视觉驱动反应。谷氨酸诱导杏仁核神经元激活或GABA诱导杏仁核神经元失活分别增强或减弱初级视皮层功能图中视觉诱发的全局信号和差分信号。这种调制被发现是非选择性的，与增益控制机制一致，优选取向及其映射取向调谐宽度保持不变。单个装置记录显示了支持上述观察结果的相似结果。这些结果表明杏仁核的远端反馈信号以非选择性、增益控制的方式增强初级感觉信息的加工。这为以往情绪线索相关的心理学研究提供了直接的神经生理学证据和启示。(C)2013 Elsevier Inc. All rights reserved.
The amygdala is an important center for emotional behavior, and it influences other cortical regions. Long feedback projections from the amygdala to the primary visual cortex were recently reported in the cat and monkey, two animal models for vision research. However, the detailed functional roles of these extensive projections still remain largely unknown. In this study, intrinsic signal optical imaging was used to investigate the visually driven responses of the primary visual cortex of cats as focal drugs were injected into the basal nucleus of the amygdala. Both the visually evoked global signals and differential signals in the functional maps of the primary visual cortex were enhanced or reduced by glutamate-induced activation or GABA-induced deactivation of neurons in the amygdala, respectively. This modulation was found to be non-selective, consistent with the gain control mechanism both the preferred orientation and its mapped orientation tuning width remained unchanged. The single unit recordings showed similar results supporting the above observations. These results suggest that the distal feedback signals of the amygdala enhance the primary sensory information processing in a non-selective, gain-control fashion. This provides direct neurophysiological evidence and insight for previous studies on emotional-cue related psychological studies. (C) 2013 Elsevier Inc. All rights reserved.