Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum
Clinical Isolate of a Multi-Antifungal-Resistant Trichophyton rubrum
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DOI：
10.1128/aac.02393-21
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发表时间：
2022-04-19
影响因子：
4.9
通讯作者：
Hiruma, Masataro
中科院分区：
文献类型：
--
作者：
Kano, Rui;Kimura, Utako;Hiruma, Masataro
从1例复发性尿道炎患者中分离出红色毛癣菌耐多药菌株NUBS 21012。耐药菌株编码Phe，而不是密码子393 Leu（L393F）的角鲨烯环氧酶（SQLE）基因。与其他菌株相比，该菌株中编码ATP结合盒转运蛋白的基因的表达增加。这一结果为ATP结合盒转运蛋白与唑类耐药密切相关提供了证据。
The multi-antifungal drug-resistant strain (NUBS21012) of Trichophyton rubrum was isolated from a patient with recurrent tinea corporis. The resistant strain encoded Phe at codon 393 instead of Leu (L393F) in the squalene epoxidase (SQLE) gene. The expression of genes encoding ATP-binding cassette transporter proteins increased in the strain compared to that of other strains. This result provides evidence that ATP-binding cassette transporter proteins are closely associated with azole resistance.