Influence of Individual and Combined Health Behaviors on Total and Cause-Specific Mortality in Men and Women The United Kingdom Health and Lifestyle Survey
Influence of Individual and Combined Health Behaviors on Total and Cause-Specific Mortality in Men and Women The United Kingdom Health and Lifestyle Survey
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DOI：
10.1001/archinternmed.2010.76
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发表时间：
2010-04-26
影响因子：
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通讯作者：
Gale, Catharine R.
中科院分区：
文献类型：
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作者：
Kvaavik, Elisabeth;Batty, G. David;Gale, Catharine R.
背景：体力活动、饮食、吸烟和饮酒已被证明与死亡率有关。我们前瞻性地研究了这些危险因素对总的和病因特异性mortality.Methods的个体和综合影响：前瞻性队列研究包括4886个人至少18岁的英国范围内的人口在1984年至1985年。计算健康行为评分，为每种不良行为分配1分：吸烟;每天食用水果和蔬菜少于3次;每周少于2小时的体力活动;每周饮酒超过14单位（女性）和超过21单位（男性）（分数范围，0-4）。我们使用考克斯模型研究了健康行为与死亡率之间的关系，并将其与老龄化相关的死亡风险进行了比较。结果：在平均20年的随访期间，1080名参与者死亡，431人死于心血管疾病，318人死于癌症，331人死于其他原因。与无不良健康行为的总死亡率相比，与1、2、3和4种不良健康行为相关的总死亡率的调整后风险比和95%置信区间（CI）为1.85（95% CI，1.28-2.68）、2.23（95% CI，1.55-3.20）、2.76（95% CI，1.91-3.99）和3.49（95% CI，2.31-5.26）（趋势P值，
Background: Physical activity, diet, smoking, and alcohol consumption have been shown to be related to mortality. We examined prospectively the individual and combined influence of these risk factors on total and cause-specific mortality.Methods: The prospective cohort study included 4886 individuals at least 18 years old from a United Kingdom-wide population in 1984 to 1985. A health behavior score was calculated, allocating 1 point for each poor behavior: smoking; fruits and vegetables consumed less than 3 times daily; less than 2 hours physical activity per week; and weekly consumption of more than 14 units of alcohol (in women) and more than 21 units (in men) (range of points, 0-4). We examined the relationship between health behaviors and mortality using Cox models and compared it with the mortality risk associated with aging.Results: During a mean follow-up period of 20 years, 1080 participants died, 431 from cardiovascular diseases, 318 from cancer, and 331 from other causes. Adjusted hazard ratios and 95% confidence intervals (CIs) for total mortality associated with 1, 2, 3, and 4 poor health behaviors compared with those with none were 1.85 (95% CI, 1.28-2.68), 2.23(95% CI, 1.55-3.20), 2.76(95% CI, 1.91-3.99), and 3.49(95% CI, 2.31-5.26), respectively (P value for trend,