Brain temperature affects quantitative features of hippocampal sharp wave ripples
Brain temperature affects quantitative features of hippocampal sharp wave ripples
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DOI：
10.1152/jn.00047.2022
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发表时间：
2022-05-01
影响因子：
2.5
通讯作者：
Buzsaki, Gyorgy
中科院分区：
文献类型：
--
作者：
Petersen, Peter C.;Voroslakos, Mihaly;Buzsaki, Gyorgy
生化机制依赖于温度。大脑温度在不同的大脑状态下表现出很大的差异，这种变化可能解释了网络振荡的数量变化。在这里，我们报告了不同的海马区尖锐波纹特征与脑温度的关系。波纹频率、出现率和持续时间与温度动态相关。通过对大脑海马区CA1区温度的聚焦操作，我们发现局部加热和降温可以分别增加和降低纹波频率。其他参数的变化，如尖锐波纹复合体的比率(SPW-R)和波纹持续时间并没有受到一致的影响。我们的发现表明，CA1区的大脑温度在影响纹波频率方面起主导作用，而SPW-Rs的其他参数可能由CA1区上游的机制决定。这些发现表明，大脑温度的生理变化对海马体回路的运作有重要影响。值得注意的是，在生理条件下，大脑温度在睡眠和活跃醒来之间波动约3摄氏度。在这里，我们展示了海马波的特征，包括出现率、峰值频率和持续时间与大脑温度变化相关。对清醒啮齿动物海马区CA1区温度的焦点双向操纵表明，纹波频率可以沿相关观察所预期的方向改变，这意味着温度起着重要作用。
Biochemical mechanisms are temperature dependent. Brain temperature shows wide variations across brain states, and such changes may explain quantitative changes in network oscillations. Here, we report on the relationship between various hippocampal sharp wave ripple features to brain temperature. Ripple frequency, occurrence rate, and duration correlated with temperature dynamics. By focal manipulation of the brain temperature in the hippocampal CA1 region, we show that ripple frequency can be increased and decreased by local heating and cooling, respectively. Changes of other parameters, such as the rate of sharp wave-ripple complex (SPW-R) and ripple duration were not consistently affected. Our findings suggest that brain temperature in the CA1 region plays a leading role in affecting ripple frequency, whereas other parameters of SPW-Rs may be determined by mechanisms upstream from the CA1 region. These findings illustrate that physiological variations of brain temperature exert important effects on hippocampal circuit operations.NEW & NOTEWORTHY During physiological conditions, brain temperature fluctuates approximately 3 degrees C between sleep and active waking. Here, we show that features of hippocampal ripples, including the rate of occurrence, peak frequency, and duration are correlated with brain temperature variations. Focal bidirectional manipulation of temperature in the hippocampal CA1 region in awake rodents show that ripple frequency can be altered in the direction expected from the correlational observations, implying that temperature plays a significant role.