DNA methylation at stress-related genes is associated with exposure to early life institutionalization.
DNA methylation at stress-related genes is associated with exposure to early life institutionalization.
复制标题
与应激相关基因处的DNA甲基化与暴露于早期生命制度化有关。
DOI：
10.1002/ajpa.23010
复制
发表时间：
2016-09
影响因子：
2.8
通讯作者：
Drury SS
中科院分区：
文献类型：
--
作者：
Non AL;Hollister BM;Humphreys KL;Childebayeva A;Esteves K;Zeanah CH;Fox NA;Nelson CA;Drury SS
Differences in DNA methylation have been associated with early life adversity, suggesting that alterations in methylation function as one pathway through which adverse early environments are biologically embedded. This study examined associations between exposure to institutional care, quantified as the percent time in institutional care at specified follow-up assessment ages, and DNA methylation status in two stress-related genes: FKBP5 and SLC6A4. We analyzed data from the Bucharest Early Intervention Project, which is a prospective study in which children reared in institutional settings were randomly assigned (mean age 22 months) to either newly created foster care or care as usual (to remain in their current placement) and prospectively followed. A group of children from the same geographic area, with no history of institutionalized caregiving, were also recruited. DNA methylation status was determined in DNA extracted from buccal epithelial cells of children at age 12. An inverse association was identified such that more time spent in institutional care was associated with lower DNA methylation at specific CpG sites within both genes. These results suggest a lasting impact of early severe social deprivation on methylation patterns in these genes, and contribute to a growing literature linking early adversity and epigenetic variation in children.
