Contribution of dendritic cell immunoreceptor (DCIR) polymorphisms in susceptibility of systemic lupus erythematosus and primary Sjogren's syndrome
Contribution of dendritic cell immunoreceptor (DCIR) polymorphisms in susceptibility of systemic lupus erythematosus and primary Sjogren's syndrome
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DOI：
10.1016/j.humimm.2015.09.040
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发表时间：
2015-11-01
期刊：
影响因子：
2.7
通讯作者：
Li, Zhanguo
中科院分区：
文献类型：
--
作者：
Liu, Mengru;Wu, Xinyu;Li, Zhanguo
树突状细胞免疫受体（DCIR）先前已显示与高加索人和汉族人的类风湿关节炎（RA）。本研究旨在进一步探讨DCIR基因多态性是否是其他自身免疫性疾病，如系统性红斑狼疮（SLE）和原发性干燥综合征（SS）的新的易感因素。共有1502例SLE患者、476例原发性SS患者和1278例非相关健康对照者入组本研究。采用TaqMan法检测rs2377422和rs10840759单核苷酸多态性（SNPs）基因型。两组间等位基因和基因型分布的差异分别采用Pearson卡方检验和经年龄和性别调整的logistic回归进行评估。p值
Dendritic cell immunoreceptor (DCIR) has previously shown an association with rheumatoid arthritis (RA) in Caucasians and Han Chinese. This study was aimed to further investigate whether DCIR polymorphisms are novel susceptibility factors for other autoimmune diseases, i.e. systemic lupus erythematosus (SLE) and primary Sjogren's syndrome (SS). A total of 1502 patients with SLE, 476 patients with primary SS, and 1278 non-related healthy controls were enrolled in the study. The single-nucleotide polymorphisms (SNPs) rs2377422 and rs10840759 were genotyped using TaqMan assay. The differences in allelic and genotypic distribution between two groups were assessed using Pearson chi-square test, and logistic regression adjusting for age and sex, respectively. P-value