Diagnostic Accuracy of Serum Matrix Metalloproteinase-7 for Biliary Atresia.
Diagnostic Accuracy of Serum Matrix Metalloproteinase-7 for Biliary Atresia.
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DOI：
10.1002/hep.30234
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Tang ST
中科院分区：
文献类型：
--
作者：
Yang L;Zhou Y;Xu PP;Mourya R;Lei HY;Cao GQ;Xiong XL;Xu H;Duan XF;Wang N;Fei L;Chang XP;Zhang X;Jiang M;Bezerra JA;Tang ST
胆道闭锁（BA）的诊断仍然是一项临床挑战，因为患病婴儿的体征、症状以及血清肝脏生化指标在其他原因导致的新生儿胆汁淤积（非BA）患儿中也可见到。然而，早期诊断和及时的手术治疗对于改善临床预后是必需的。近期，血清基质金属蛋白酶 - 7（MMP - 7）的相对丰度被认为对BA患儿具有鉴别特征。为了验证血清MMP - 7浓度升高对BA具有高度诊断性这一假设，我们测定了健康对照婴儿的血清MMP - 7正常浓度，然后测定了135例因胆汁淤积接受评估的连续婴儿的血清MMP - 7浓度。正常对照组中MMP - 7的中位浓度为2.86 ng/mL（四分位间距，IQR：1.32 - 5.32），非BA组为11.47 ng/mL（IQR：8.54 - 24.55），BA组为121.1 ng/mL（IQR：85.42 - 224.4）（P < 0.0001）。MMP - 7诊断BA的曲线下面积为0.9900，截断值为52.85 ng/mL；诊断敏感性和特异性分别为98.67%和95.00%，阴性预测值为98.28%。结论：血清MMP - 7检测在区分BA与其他新生儿胆汁淤积方面具有高敏感性和特异性，可能是BA的一种可靠生物标志物。
The diagnosis of biliary atresia (BA) remains a clinical challenge because affected infants have signs, symptoms, and serum liver biochemistry that are also seen in those with other causes of neonatal cholestasis (non‐BA). However, an early diagnosis and prompt surgical treatment are required to improve clinical outcome. Recently, the relative abundance of serum matrix metalloproteinase‐7 (MMP‐7) was suggested to have discriminatory features for infants with BA. To test the hypothesis that elevated serum concentration of MMP‐7 is highly diagnostic for BA, we determined the normal serum concentration of MMP‐7 in healthy control infants, and then in 135 consecutive infants being evaluated for cholestasis. The median concentration for MMP‐7 was 2.86 ng/mL (interquartile range, IQR: 1.32‐5.32) in normal controls, 11.47 ng/mL (IQR: 8.54‐24.55) for non‐BA, and 121.1 ng/mL (IQR: 85.42‐224.4) for BA (P < 0.0001). The area under the curve of MMP‐7 for the diagnosis of BA was 0.9900 with a cutoff value of 52.85 ng/mL; the diagnostic sensitivity and specificity were 98.67% and 95.00%, respectively, with a negative predictive value of 98.28%. Conclusion: Serum MMP‐7 assay has high sensitivity and specificity to differentiate BA from other neonatal cholestasis, and may be a reliable biomarker for BA.
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影响因子：
12.6
作者：
Russo, Pierre;Magee, John C.;Boitnott, John;Bove, Kevin E.;Raghunathan, Trivellore;Finegold, Milton;Haas, Joel;Jaffe, Ronald;Kim, Grace E.;Magid, Margret;Melin-Aldana, Hector;White, Frances;Whitington, Peter F.;Sokol, Ronald J.
通讯作者：
Sokol, Ronald J.
影响因子：
13.5
作者：
Hung, Tzu-Min;Chang, Shin C.;Chang, Ming-Fu
通讯作者：
Chang, Ming-Fu
影响因子：
4.6
作者：
Sundaram, Shikha S.;Mack, Cara L.;Feldman, Amy G.;Sokol, Ronald J.
通讯作者：
Sokol, Ronald J.
DOI：
10.1002/cjp2.50
发表时间：
2016-07
期刊：
The journal of pathology. Clinical research
影响因子：
--
作者：
Kerola A;Lampela H;Lohi J;Heikkilä P;Mutanen A;Hagström J;Tervahartiala T;Sorsa T;Haglund C;Jalanko H;Pakarinen MP
通讯作者：
Pakarinen MP
影响因子：
7.5
作者：
Huang, CC;Chuang, JH;Tai, MH
通讯作者：
Tai, MH