Development of long-term subsensitivity to GABA in dorsal raphe neurons of amygdala-kindled rats.
Development of long-term subsensitivity to GABA in dorsal raphe neurons of amygdala-kindled rats.
复制标题
杏仁核点燃大鼠中缝背神经元对 GABA 长期不敏感的发展。
DOI：
10.1016/0006-8993(92)90136-w
复制
发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Gallager,DW
中科院分区：
文献类型：
--
作者：
Hernandez,TD;Gallager,DW
之前我们报道了杏仁核点燃后神经元对 GABA 敏感性的长期变化12。杏仁核点燃大鼠的中缝背侧神经元在最后一次完全全身性（第 5 阶段）癫痫发作 4 周后表现出对 GABA 的显着不敏感。我们假设 GABA 敏感性的这种变化可能反映了与点燃的癫痫易感性相对应的神经元变化，随后的实验已经研究了这一假设。杏仁核点燃期间神经元对 GABA 不敏感的进展可能与动物被点燃的阶段相关。也就是说，在最后一次癫痫发作后 4 周进行测量时，中缝背侧神经元在第 2 阶段癫痫发作后对 GABA 超级敏感，与第 3 阶段癫痫发作后的对照没有不同，并且在第 5 阶段癫痫发作后对 GABA 敏感。此外，对 GABA 的不敏感性似乎是永久性的，因为在最后一次 5 期癫痫发作 3 个月后仍然可以测量到。因此，杏仁核点燃会导致神经元对 GABA 的敏感性发生长期的、也许是永久性的变化，这些变化反映了动物被点燃的阶段。
Previously we reported a long-term change in neuronal sensitivity to GABA following amygdala kindling12. Dorsal raphe neurons of amygdala-kindled rats exhibited significant subsensitivity to GABA 4 weeks after the last fully generalized (Stage 5) seizure. We hypothesized that this alteration in GABA sensitivity might reflect neuronal changes corresponding to kindled seizure susceptibility and subsequent experiments have investigated thus hypothesis. The progression towards neuronal subsensitivity to GABA during amygdala kindling can be correlated with the Stage to which an animal has been kindled. That is, when measured 4 weeks after the last kindled seizure, dorsal raphe neurons aresupersensitiveto GABA following a Stage 2 seizure,not different from controlsfollowing a Stage 3 seizure andsubsensitiveto GABA following a Stage 5 seizure. In addition, subsensitivity to GABA appears to be permanent in that it is still measurable 3 months after the last Stage 5 seizure. Thus, amygdala kindling produces long-term, perhaps permanent, changes in neuronal sensitivity to GABA and these changes reflect the Stage to which an animal has been kindled.