Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus
Six months of aerobic exercise does not improve microvascular function in type 2 diabetes mellitus
复制标题
DOI：
10.1007/s00125-006-0361-x
复制
发表时间：
2006-10-01
期刊：
影响因子：
8.2
通讯作者：
Tooke, J. E.
中科院分区：
文献类型：
--
作者：
Middlebrooke, A. R.;Elston, L. M.;Tooke, J. E.
目的/假设成人2型糖尿病患者微血管功能受损。据推测，微血管功能可以通过定期锻炼恢复。本研究旨在探讨6个月的规律有氧运动是否能改善2型糖尿病患者的微血管功能。（32名男性，年龄62.9 +/- 7.6岁，HbA（1c）6.8 +/- 0.9%）被随机分配至6个月的有氧运动项目组和10个月的有氧运动项目组。（30分钟，每周三次，最大心率的70-80%）或“标准护理”对照组。在干预期间之前和之后，微血管功能被评估为在乙酰胆碱和硝普钠的离子电渗应用之后对局部加热和内皮和非内皮反应性的最大皮肤充血。最大摄氧量，作为有氧健身的一个指标，使用最大运动test.Results评估没有显着改善被视为在运动组与对照组相比的任何变量测量：最大摄氧量（对照前：1.73 +/- 0.53 [均值+/- SD] vs后：1.67 +/- 0.40;运动前：1.75 +/- 0.56 vs后：1.87 +/- 0.62 l/min，p=0.10）;胰岛素敏感性（胰岛素耐量试验）（对照前：-0.17 +/- 0.06 vs后：-0.17 +/- 0.06;运动前：-0.16 +/- 0.1 vs后：-0.17 +/- 0.07 mmol l（-1）p min（-1），p=0.97）;最大充血（对照前：1.49 ± 0.43 vs后：1.52 ± 0.57;运动前：1.42 ± 0.36 vs后：1.47 ± 0.33 V，p=0.85）;对乙酰胆碱的峰值反应（对照前：1.37 ± 0.47 vs后：1.28 ± 0.37;运动前：1.27 ± 0.44 vs后：1.44 ± 0.23 V，p=0.19）或硝普钠（对照组术前：1.09 +/- 0.50 vs术后：1.10 +/- 0.39;运动组术前：1.12 +/- 0.28 vs术后：1.13 +/- 0.40 V，p=0.98）。结论/解释在这组血糖控制良好的2型糖尿病患者中，一个月的有氧运动计划没有改善微血管功能或有氧健身。
Aims/hypothesis Adults with type 2 diabetes mellitus have impaired microvascular function. It has been hypothesised that microvascular function may be restored through regular exercise. The aim of this study was to investigate whether 6 months of regular aerobic exercise would improve microvascular function in adults with type 2 diabetes.Materials and methods Fifty-nine patients with type 2 diabetes (32 males, age 62.9 +/- 7.6 years, HbA(1c) 6.8 +/- 0.9%) were randomised to either a 6-month aerobic exercise programme (30 min, three times a week, 70-80% of maximal heart rate) or a 'standard care' control group. Before and after the intervention period, microvascular function was assessed as the maximum skin hyperaemia to local heating and endothelial and non-endothelial responsiveness following the iontophoretic application of acetylcholine and sodium nitroprusside. Maximal oxygen uptake, as an index of aerobic fitness, was assessed using a maximal exercise test.Results No significant improvement was seen in the exercise group compared with the control group for any of the variables measured: maximal oxygen uptake (control pre: 1.73 +/- 0.53 [means +/- SD] vs post: 1.67 +/- 0.40; exercise pre: 1.75 +/- 0.56 vs post: 1.87 +/- 0.62 l/min, p=0.10); insulin sensitivity (insulin tolerance test) (control pre: -0.17 +/- 0.06 vs post: -0.17 +/- 0.06; exercise pre: -0.16 +/- 0.1 vs post: -0.17 +/- 0.07 mmol l(-1) p min(-1), p=0.97); maximal hyperaemia (control pre: 1.49 +/- 0.43 vs post: 1.52 +/- 0.57; exercise pre: 1.42 +/- 0.36 vs post: 1.47 +/- 0.33 V, p=0.85); peak response to acetylcholine (control pre: 1.37 +/- 0.47 vs post: 1.28 +/- 0.37; exercise pre: 1.27 +/- 0.44 vs post: 1.44 +/- 0.23 V, p=0.19) or to sodium nitroprusside (control pre: 1.09 +/- 0.50 vs post: 1.10 +/- 0.39; exercise pre: 1.12 +/- 0.28 vs post: 1.13 +/- 0.40 V, p=0.98).Conclusions/interpretation In this group of type 2 diabetic patients with good glycaemic control a 6-month aerobic exercise programme did not improve microvascular function or aerobic fitness.