Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations
Malignant peripheral nerve sheath tumor: Molecular pathogenesis and current management considerations
复制标题
DOI：
10.1002/jso.20971
复制
发表时间：
2008-03-15
影响因子：
2.5
通讯作者：
Hochwald, Steven N.
中科院分区：
文献类型：
--
作者：
Grobmyer, Stephen R.;Reith, John D.;Hochwald, Steven N.
恶性外周神经鞘瘤（MPNST）是一种罕见的肿瘤，常发生在神经纤维瘤病1型患者中。手术切除是治疗的主要手段。放疗和化疗在选定的MPNST患者中发挥作用。在许多MPNST病例中，准确的病理诊断仍然是一个挑战。最近在MPNST的分子发病机制的理解方面取得了许多进展，这代表了开发MPNST患者管理新策略的最佳机会。
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are rare tumors that often occur in patients with neurofibromatosis 1. Surgical resection represents the mainstay of treatment. Radiation and chemotherapy have a role in selected patients with MPNST. Accurate pathologic diagnosis remains a challenge in many cases of MPNST. There are many recent advances in the understanding of the molecular pathogenesis of MPNST which represent the best opportunities to develop new strategies for management of patients with MPNST.